Diagnostic value of radial endobronchial ultrasonographic features in predominant solid peripheral pulmonary lesions

Xiaoxuan Zheng; Lei Wang; Jie Chen; Fangfang Xie; Yifeng Jiang; Jiayuan Sun

doi:10.21037/jtd-2020-abpd-004

Diagnostic value of radial endobronchial ultrasonographic features in predominant solid peripheral pulmonary lesions

J Thorac Dis. 2020 Dec;12(12):7656-7665. doi: 10.21037/jtd-2020-abpd-004.

Authors

Xiaoxuan Zheng^{1

2

3}, Lei Wang⁴, Jie Chen⁴, Fangfang Xie^{1

2

3}, Yifeng Jiang⁵, Jiayuan Sun^{1

2

3}

Affiliations

¹ Department of Respiratory Endoscopy, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China.
² Department of Respiratory and Critical Care Medicine, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China.
³ Shanghai Engineering Research Center of Respiratory Endoscopy, Shanghai, China.
⁴ Department of Ultrasound, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China.
⁵ Radiology Department, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China.

Abstract

Background: Transbronchial lung biopsy (TBLB) of peripheral pulmonary lesions (PPLs) is usually performed for a definite diagnosis. Radial probe endobronchial ultrasonography is often acknowledged as a good guidance method for TBLB as it can help physicians confirm the lesions' position. It is also a non-invasive imaging diagnostic method. This clinical study was designed to evaluate the ability of radial endobronchial ultrasonography (R-EBUS) to differentiate benign from malignant predominant solid PPLs based on imaging features.

Methods: Patients with predominant solid PPLs were enrolled in this study retrospectively. TBLB was performed using R-EBUS with or without other guidance techniques. One typical sonographic image and one video of each lesion were recorded for analysis. Six radial probe endobronchial ultrasonographic image features (size, shape, echogenicity, margin, blood vessel, and linear-discrete air bronchogram) were studied by ultrasonography specialists and physicians who were blinded to the final diagnosis. The sum score model of the combined predictive factors indicated the best diagnostic accuracies for predicting malignant PPLs. The model group results were used to establish the diagnostic standard for a verification group.

Results: A total of 303 patients were enrolled in the model group from July 2018 to July 2019 at the Shanghai Chest Hospital (214 with malignant and 89 with benign lesions). The mean lesion long axis on computed tomographic images was 34.39±13.79 mm. There were significant statistical differences between benign and malignant lesions in the long axis, short axis, shape, margin, blood vessel, and linear-discrete air bronchogram assessed by radial endobronchial ultrasound. Long axis, lobulation, distinct but not sharp margin, absence of blood vessel, and absence of linear-discrete air bronchogram were good predictive factors of malignant lesions. A sum score model value of 79.54% of these combined factors indicated the best diagnostic accuracy for predicting malignant lesions. Eighty-seven patients were enrolled in the verification group from August to October 2019. The sum score model showed a diagnostic accuracy of 82.76%.

Conclusions: Radial endobronchial ultrasonographic features can differentiate malignant from benign lesions and thus have potential diagnosis value in predominant solid PPLs.

Keywords: Transbronchial lung biopsy (TBLB); lung cancer; peripheral pulmonary lesions (PPLs); radial endobronchial ultrasonography imaging (R-EBUS imaging).