Orchestrating soft tissue integration at the transmucosal region of titanium implants

Tianqi Guo; Karan Gulati; Himanshu Arora; Pingping Han; Benjamin Fournier; Sašo Ivanovski

doi:10.1016/j.actbio.2021.01.001

Orchestrating soft tissue integration at the transmucosal region of titanium implants

Acta Biomater. 2021 Apr 1:124:33-49. doi: 10.1016/j.actbio.2021.01.001. Epub 2021 Jan 12.

Authors

Tianqi Guo¹, Karan Gulati², Himanshu Arora¹, Pingping Han¹, Benjamin Fournier³, Sašo Ivanovski⁴

Affiliations

¹ The University of Queensland, School of Dentistry, Herston QLD 4006, Australia.
² The University of Queensland, School of Dentistry, Herston QLD 4006, Australia. Electronic address: k.gulati@uq.edu.au.
³ The University of Queensland, School of Dentistry, Herston QLD 4006, Australia; Universite de Paris, Dental Faculty Garanciere. Oral Biology Department. Centre of Reference for Oral Rare Diseases. Paris, France; Centre de Recherche des Cordeliers, Universite de Paris, Sorbonne Universite, INSERM UMRS 1138, Molecular Oral Pathophysiology, Paris, France.
⁴ The University of Queensland, School of Dentistry, Herston QLD 4006, Australia. Electronic address: s.ivanovski@uq.edu.au.

PMID: 33444803
DOI: 10.1016/j.actbio.2021.01.001

Abstract

Osseointegration at the bone-implant interface and soft tissue integration (STI) at the trans-mucosal region are crucial for the long-term success of dental implants, especially in compromised patient conditions. The STI quality of conventional smooth and bio-inert titanium-based implants is inferior to that of natural tissue (i.e. teeth), and hence various surface modifications have been suggested. This review article compares and contrasts the various modification strategies (physical, chemical and biological) utilized to enhance STI of Ti implants. It also details the STI challenges associated with conventional Ti-based implants, current surface modification strategies and cutting-edge nano-engineering solutions. The topographical, biological and therapeutic advances achievable via electrochemically anodized Ti implants with TiO₂ nanotubes/nanopores are highlighted. Finally, the status and future directions of such nano-engineered implants is discussed, with emphasis on bridging the gap between research and clinical translation.

Keywords: Anodization; Dental abutments; Dental implants; Fibroblasts; Soft-tissue integration; Titanium.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Dental Implants*
Humans
Nanopores*
Nanotubes*
Osseointegration
Prostheses and Implants
Surface Properties
Titanium

Substances

Dental Implants
Titanium