Rhodium(III)-catalyzed oxidative alkylation of N-aryl-7-azaindoles with cyclopropanols

Jidan Liu; Jinyuan Jiang; Zhenke Yang; Qiaohai Zeng; Jieying Zheng; Siying Zhang; Liyao Zheng; Shang-Shi Zhang; Zhao-Qing Liu

doi:10.1039/d0ob02323j

Rhodium(III)-catalyzed oxidative alkylation of N-aryl-7-azaindoles with cyclopropanols

Org Biomol Chem. 2021 Feb 11;19(5):993-997. doi: 10.1039/d0ob02323j.

Authors

Jidan Liu¹, Jinyuan Jiang¹, Zhenke Yang¹, Qiaohai Zeng¹, Jieying Zheng¹, Siying Zhang¹, Liyao Zheng¹, Shang-Shi Zhang², Zhao-Qing Liu¹

Affiliations

¹ School of Chemistry and Chemical Engineering/Institute of Clean Energy and Materials/Guangzhou Key Laboratory for Clean Energy and Materials, Guangzhou University, Guangzhou, 510006, P. R. China. jdliu@gzhu.edu.cn lzqgzu@gzhu.edu.cn.
² Center for Drug Research and Development, Guangdong Pharmaceutical University, Guangzhou, 510006, P. R. China.

PMID: 33443262
DOI: 10.1039/d0ob02323j

Abstract

An efficient Rh(iii)-catalyzed C-H oxidative alkylation of N-aryl-7-azaindoles with cyclopropanols by merging tandem C-H and C-C cleavage was developed. This transformation features mild reaction conditions, high regioselectivity, and excellent functional group compatibility. The resulting β-aryl ketone derivatives can be readily transformed into 7-azaindole-containing π-extended polycyclic heteroarenes.