Increased O-GlcNAcylation prevents degeneration of dopamine neurons

Gerald W Hart; Chia-Wei Huang

doi:10.1093/brain/awaa398

Increased O-GlcNAcylation prevents degeneration of dopamine neurons

Brain. 2020 Dec 1;143(12):3515-3518. doi: 10.1093/brain/awaa398.

Authors

Gerald W Hart¹, Chia-Wei Huang¹

Affiliation

¹ Department of Biochemistry and Molecular Biology, Complex Carbohydrate Research Center, University of Georgia, Athens, GA 30602, USA.

Abstract

This scientific commentary refers to ‘O-GlcNAcylation regulates dopamine neuron function, survival and degeneration in Parkinson disease’, by Lee et al. (doi:10.1093/brain/awaa320).

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Dopaminergic Neurons*
Glycosylation
Humans
Parkinson Disease*
Phosphorylation

Grants and funding

R01 GM116891/GM/NIGMS NIH HHS/United States