Low-dose colchicine prevents sympathetic denervation after myocardial ischemia-reperfusion: a new potential protective mechanism

Fabien Huet; Jérémy Fauconnier; Marion Legall; Pierre Sicard; Catherine Lozza; Alain Lacampagne; François Roubille

doi:10.2144/fsoa-2020-0151

Low-dose colchicine prevents sympathetic denervation after myocardial ischemia-reperfusion: a new potential protective mechanism

Future Sci OA. 2020 Nov 23;7(2):FSO656. doi: 10.2144/fsoa-2020-0151.

Authors

Fabien Huet^{1

2}, Jérémy Fauconnier², Marion Legall², Pierre Sicard², Catherine Lozza², Alain Lacampagne², François Roubille^{1

2}

Affiliations

¹ Department of Cardiology, Montpellier University Hospital, Montpellier, Occitanie, France.
² University of Montpellier, CNRS, INSERM, CHRU Montpellier, Montpellier, France.

Abstract

Purpose: To evaluate the impact of colchicine on sympathetic denervation after acute myocardial infarction (AMI).

Materials & methods: Ischemia/Reperfusion was induced in C57BL/6J male mice. Left coronary artery was ligated during 45 min followed by reperfusion. 400 μg/kg of colchicine or the placebo was administrated intraperitoneally 15 min before the reperfusion.

Results: Colchicine treatment significantly improved heart rate variability index after AMI. Colchicine prevented sympathetic denervation in the remote area (p = 0.04) but not in the scar area (p = 0.70).

Conclusion: These results suggest promising protective pathway of colchicine after AMI.

Keywords: colchicine; heart rate variability; myocardial infarction; sympathetic innervation.