The NCI-MATCH: A National, Collaborative Precision Oncology Trial for Diverse Tumor Histologies

Yonina R Murciano-Goroff; Alexander Drilon; Zsofia K Stadler

doi:10.1016/j.ccell.2020.12.021

The NCI-MATCH: A National, Collaborative Precision Oncology Trial for Diverse Tumor Histologies

Cancer Cell. 2021 Jan 11;39(1):22-24. doi: 10.1016/j.ccell.2020.12.021.

Authors

Yonina R Murciano-Goroff¹, Alexander Drilon², Zsofia K Stadler³

Affiliations

¹ Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
² Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Weill Cornell Medical College, New York, NY, USA.
³ Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Weill Cornell Medical College, New York, NY, USA. Electronic address: stadlerz@mskcc.org.

Abstract

The NCI-MATCH is a national master protocol trial, published in the Journal of Clinical Oncology, in which diverse tumors are sequenced and patients assigned to treatment. The trial demonstrates the feasibility of identifying rare and common actionable genetic alterations and underscores the strength of academic/community partnerships for improving trial access.

MeSH terms

Clinical Trials as Topic
Feasibility Studies
Humans
Interdisciplinary Communication
Molecular Targeted Therapy
Mutation*
Neoplasms / drug therapy*
Neoplasms / genetics
Precision Medicine / methods*
Rare Diseases
Sample Size
Sequence Analysis, DNA / methods*
Time Factors

Grants and funding

P30 CA008748/CA/NCI NIH HHS/United States