Attribution studies have identified a robust anthropogenic fingerprint in increased 21st century wildfire risk. However, the risks associated with individual aspects of anthropogenic aerosol and greenhouse gases (GHG) emissions, biomass burning and land use/land cover change remain unknown. Here, we use new climate model large ensembles isolating these influences to show that GHG-driven increases in extreme fire weather conditions have been balanced by aerosol-driven cooling throughout the 20th century. This compensation is projected to disappear due to future reductions in aerosol emissions, causing unprecedented increases in extreme fire weather risk in the 21st century as GHGs continue to rise. Changes to temperature and relative humidity drive the largest shifts in extreme fire weather conditions; this is particularly apparent over the Amazon, where GHGs cause a seven-fold increase by 2080. Our results allow increased understanding of the interacting roles of anthropogenic stressors in altering the regional expression of future wildfire risk.