Abdominal pain with intra-adrenal bleeding as an initial presentation of pheochromocytoma

BMJ Case Rep. 2021 Jan 11;14(1):e237975. doi: 10.1136/bcr-2020-237975.

Abstract

A 55-year-old man presented with severe right upper quadrant abdominal pain and hypertension up to 231/171 mm Hg on a background of a known adrenal mass, intravenous drug use and recurrent anxiety attacks. CT showed heterogenous lesion of the right adrenal gland but the sudden severe pain remained unexplained. After correction of the blood pressure with analgesia and antihypertensives, the patient developed a type 2 non-ST-elevation myocardial infarction that was treated with aspirin and therapeutic enoxaparin. This resulted in worsening pain and a repeat CT angiogram showed a haemoretroperitoneum around the right adrenal lesion. On review, an occult intra-adrenal haemorrhage was identified on the initial CT scan. Presumably this concealed haemorrhage caused the initial pain crisis and later decompressed into the retroperitoneal space. Raised metanephrine levels confirmed the diagnosis of pheochromocytoma and after preoperative optimisation with phenoxybenzamine, an open right adrenalectomy was performed.

Keywords: adrenal disorders; adult intensive care; hypertension; radiology (diagnostics); surgery.

Publication types

  • Case Reports

MeSH terms

  • Abdominal Pain / diagnosis
  • Abdominal Pain / etiology*
  • Adrenal Gland Neoplasms / blood
  • Adrenal Gland Neoplasms / complications
  • Adrenal Gland Neoplasms / diagnosis*
  • Adrenal Gland Neoplasms / surgery
  • Adrenal Glands / diagnostic imaging
  • Adrenal Glands / pathology
  • Adrenal Glands / surgery
  • Adrenalectomy
  • Antihypertensive Agents / administration & dosage
  • Computed Tomography Angiography
  • Electrocardiography
  • Hemorrhage / blood
  • Hemorrhage / diagnosis*
  • Hemorrhage / etiology
  • Hemorrhage / surgery
  • Humans
  • Hypertension / blood
  • Hypertension / drug therapy
  • Hypertension / etiology*
  • Male
  • Metanephrine / blood
  • Middle Aged
  • Myocardial Infarction / blood
  • Myocardial Infarction / diagnosis*
  • Myocardial Infarction / drug therapy
  • Myocardial Infarction / etiology
  • Pain Measurement
  • Pheochromocytoma / blood
  • Pheochromocytoma / complications
  • Pheochromocytoma / diagnosis*
  • Pheochromocytoma / surgery
  • Retroperitoneal Space
  • Tomography, X-Ray Computed

Substances

  • Antihypertensive Agents
  • Metanephrine