An tetraphenylethylene-based MOF (HNU-49) has been synthesized, which exhibits interesting piezofluorochromic behavior. Additionally, rhodamine B (RhB) can be successful encapsulated in HNU-49, to emit the characteristic dual-emission of RhB and the framework. The combination of host-guest interaction and piezofluorochromism can precisely modulate the luminescence to achieve near white-light.