Probiotics in the add-on treatment of rhinosinusitis: a clinical experience

I La Mantia; M Gelardi; L Drago; S E Aragona; G Cupido; C Vicini; C Berardi; G Ciprandi; Italian Study Group on Upper Respiratory Infections: Albanese G, Anni A, Antoniacomi G, Artoni S,Asprella G, Azzaro R, Azzolin A, Balduzzi A, Barbarino I, Berardi C, Bertetto BI, Bianchi A, Bianco N,Bonanno A, Bordonaro C, Brindisi AM, Bucolo S, Bulzomì AG, Caligo G, Capaccio P, Capelli M, Capone A,Carboni S, Carluccio G, Casaula M, Cassano M, Cavaliere M, Ciabattoni A, Conti A, Cordier A, Cortellessa F,Costanzo M, Cupido F, D’Ascanio L, Danza C, D’Auria C, De Ciccio M, De Luca C, D’Emila M, Dessi R,Di Lullo A, D’Urso M, Falcetti S, Falciglia R, Fera G, Ferrari G, Ferraro SM, Fini O, Fiorella M, Floriddia A,Asprea F, Fusco C, Fuson R, Gallo A, Gambardella T, Gambardella G, Giangregorio F, Gramellini G, Ierace M, Ingria F, La Paglia A, Lanza L, Lauletta R, Lavazza P, Leone M, Lovotti P, Luperto P, Maniscalco F,Marincolo I, Martone R, Melis A, Messina A, Milone V, Mirra N, Montanaro SC, Muià F, Nacci A, Nardello E,Paderno L, Padovani D, Palma A, Paoletti M, Pedrotti I, Petrillo F, Piccolo M, Pinto P, Policarpo M, Raguso M,Ranieri A, Romano G, Rondinelli M, Russo C, Scotto Di Santillo L, Sequino G, Serraino EM, Spahiu I, Spanò G,Stabile C, Stagni G, Stellin M, Tassi S, Tomacelli G, Tombolini A, Valenzise V, Zirone A

Probiotics in the add-on treatment of rhinosinusitis: a clinical experience

J Biol Regul Homeost Agents. 2020 Nov-Dec;34(6 Suppl. 1):27-34.

Authors

I La Mantia¹, M Gelardi², L Drago³, S E Aragona⁴, G Cupido⁵, C Vicini⁶, C Berardi⁷, G Ciprandi⁸; Italian Study Group on Upper Respiratory Infections: Albanese G, Anni A, Antoniacomi G, Artoni S,Asprella G, Azzaro R, Azzolin A, Balduzzi A, Barbarino I, Berardi C, Bertetto BI, Bianchi A, Bianco N,Bonanno A, Bordonaro C, Brindisi AM, Bucolo S, Bulzomì AG, Caligo G, Capaccio P, Capelli M, Capone A,Carboni S, Carluccio G, Casaula M, Cassano M, Cavaliere M, Ciabattoni A, Conti A, Cordier A, Cortellessa F,Costanzo M, Cupido F, D’Ascanio L, Danza C, D’Auria C, De Ciccio M, De Luca C, D’Emila M, Dessi R,Di Lullo A, D’Urso M, Falcetti S, Falciglia R, Fera G, Ferrari G, Ferraro SM, Fini O, Fiorella M, Floriddia A,Asprea F, Fusco C, Fuson R, Gallo A, Gambardella T, Gambardella G, Giangregorio F, Gramellini G, Ierace M, Ingria F, La Paglia A, Lanza L, Lauletta R, Lavazza P, Leone M, Lovotti P, Luperto P, Maniscalco F,Marincolo I, Martone R, Melis A, Messina A, Milone V, Mirra N, Montanaro SC, Muià F, Nacci A, Nardello E,Paderno L, Padovani D, Palma A, Paoletti M, Pedrotti I, Petrillo F, Piccolo M, Pinto P, Policarpo M, Raguso M,Ranieri A, Romano G, Rondinelli M, Russo C, Scotto Di Santillo L, Sequino G, Serraino EM, Spahiu I, Spanò G,Stabile C, Stagni G, Stellin M, Tassi S, Tomacelli G, Tombolini A, Valenzise V, Zirone A⁹

Affiliations

¹ Unit of Otolaryngology, Department of General Surgery and Medical-Surgical Specialties, University of Catania, Catania, Italy.
² Department of Otolaryngology, University of Foggia, Foggia, Italy.
³ Microbiology Department, University of Milan, Milan, Italy.
⁴ Center of Regenerative Medicine, Humanitas Mater Domini, Castellanza (VA), Italy.
⁵ ENT Department, University of Palermo, Palermo, Italy.
⁶ ENT Department, Forlì-Faenza Hospital, Italy, University of Ferrara e Bologna.
⁷ ENT Department, Istituto Clinico Città Studi di Milano, Milan, Italy.
⁸ Allergy Clinic, Casa di Cura Villa Montallegro, Genoa, Italy.
⁹ The Italian Study Group on Upper Respiratory Infections.

PMID: 33426863

Abstract

Rhinosinusitis (RS) affects the nose and the paranasal sinus and is characterized by nasal and systemic symptoms. It may be classified as acute or chronic, based on duration. Rhinosinusitis may be clinically suspected, but the diagnosis is usually based on the endoscopy. Antibiotic therapy is frequently used for RS patients in clinical practice. However, antibiotics often induce intestinal dysbiosis associated with some clinical problems and respiratory microbiota impairment. The current clinical experience was conducted in patients with pharyngotonsillitis and treated with antibiotics. A one-month course of a probiotic mixture (Abincol® containing Lactobacillus plantarum LP01 (1 billion of living cells), Lactobacillus lactis subspecies cremoris LLC02 (800 million living cells), and Lactobacillus delbrueckii LDD01 (200 million living cells), was prescribed in the Group A, and was compared with no addon treatment, such as the Group B. Patients were evaluated at baseline (T0), at the end of antibiotic treatment (T1), at the end of probiotic course (T2), and at the end of 3-month follow-up (T3).

Keywords: acute; antibiotic therapy; chronic; dysbiosis; probiotics; rhinosinusitis.

Publication types

Review

MeSH terms

Anti-Bacterial Agents / therapeutic use
Dysbiosis / drug therapy
Humans
Lactobacillus
Otitis Media*
Probiotics*

Substances

Anti-Bacterial Agents