Probiotics in the add-on treatment of otitis media in clinical practice

M Gelardi; I La Mantia; L Drago; G Meroni; S E Aragona; G Cupido; C Vicini; C Berardi; G Ciprandi; Italian Study Group on Upper Respiratory Infections: Albanese G, Anni A, Antoniacomi G, Artoni S,
Asprella G, Azzaro R, Azzolin A, Balduzzi A, Barbarino I, Berardi C, Bertetto BI, Bianchi A, Bianco N,
Bonanno A, Bordonaro C, Brindisi AM, Bucolo S, Bulzomì AG, Caligo G, Capaccio P, Capelli M, Capone A,
Carboni S, Carluccio G, Casaula M, Cassano M, Cavaliere M, Ciabattoni A, Conti A, Cordier A, Cortellessa F,
Costanzo M, Cupido F, D’Ascanio L, Danza C, D’Auria C, De Ciccio M, De Luca C, D’Emila M, Dessi R,
Di Lullo A, D’Urso M, Falcetti S, Falciglia R, Fera G, Ferrari G, Ferraro SM, Fini O, Fiorella M, Floriddia A,
Asprea F, Fusco C, Fuson R, Gallo A, Gambardella T, Gambardella G, Giangregorio F, Gramellini G, Ierace M, 
Ingria F, La Paglia A, Lanza L, Lauletta R, Lavazza P, Leone M, Lovotti P, Luperto P, Maniscalco F,
Marincolo I, Martone R, Melis A, Messina A, Milone V, Mirra N, Montanaro SC, Muià F, Nacci A, Nardello E,
Paderno L, Padovani D, Palma A, Paoletti M, Pedrotti I, Petrillo F, Piccolo M, Pinto P, Policarpo M, Raguso M,
Ranieri A, Romano G, Rondinelli M, Russo C, Scotto Di Santillo L, Sequino G, Serraino EM, Spahiu I, Spanò G,
Stabile C, Stagni G, Stellin M, Tassi S, Tomacelli G, Tombolini A, Valenzise V, Zirone A

Probiotics in the add-on treatment of otitis media in clinical practice

J Biol Regul Homeost Agents. 2020 Nov-Dec;34(6 Suppl. 1):19-26.

Authors

M Gelardi¹, I La Mantia², L Drago³, G Meroni³, S E Aragona⁴, G Cupido⁵, C Vicini⁶, C Berardi⁷, G Ciprandi⁸; Italian Study Group on Upper Respiratory Infections: Albanese G, Anni A, Antoniacomi G, Artoni S, Asprella G, Azzaro R, Azzolin A, Balduzzi A, Barbarino I, Berardi C, Bertetto BI, Bianchi A, Bianco N, Bonanno A, Bordonaro C, Brindisi AM, Bucolo S, Bulzomì AG, Caligo G, Capaccio P, Capelli M, Capone A, Carboni S, Carluccio G, Casaula M, Cassano M, Cavaliere M, Ciabattoni A, Conti A, Cordier A, Cortellessa F, Costanzo M, Cupido F, D’Ascanio L, Danza C, D’Auria C, De Ciccio M, De Luca C, D’Emila M, Dessi R, Di Lullo A, D’Urso M, Falcetti S, Falciglia R, Fera G, Ferrari G, Ferraro SM, Fini O, Fiorella M, Floriddia A, Asprea F, Fusco C, Fuson R, Gallo A, Gambardella T, Gambardella G, Giangregorio F, Gramellini G, Ierace M, Ingria F, La Paglia A, Lanza L, Lauletta R, Lavazza P, Leone M, Lovotti P, Luperto P, Maniscalco F, Marincolo I, Martone R, Melis A, Messina A, Milone V, Mirra N, Montanaro SC, Muià F, Nacci A, Nardello E, Paderno L, Padovani D, Palma A, Paoletti M, Pedrotti I, Petrillo F, Piccolo M, Pinto P, Policarpo M, Raguso M, Ranieri A, Romano G, Rondinelli M, Russo C, Scotto Di Santillo L, Sequino G, Serraino EM, Spahiu I, Spanò G, Stabile C, Stagni G, Stellin M, Tassi S, Tomacelli G, Tombolini A, Valenzise V, Zirone A⁹

Affiliations

¹ Department of Otolaryngology, University of Foggia, Foggia, Italy.
² Unit of Otolaryngology, Department of General Surgery and Medical-Surgical Specialties, University of Catania, Catania, Italy.
³ Microbiology Department, University of Milan, Milan, Italy.
⁴ Center of Regenerative Medicine, Humanitas Mater Domini, Castellanza (VA), Italy.
⁵ ENT Department, University of Palermo, Palermo, Italy.
⁶ ENT Department, Forlì-Faenza Hospital, Italy, University of Ferrara e Bologna.
⁷ ENT Department, Istituto Clinico Città Studi di Milano, Milan, Italy.
⁸ Allergy Clinic, Casa di Cura Villa Montallegro, Genoa, Italy.
⁹ The Italian Study Group on Upper Respiratory Infections.

PMID: 33426862

Abstract

Otitis media (OM) affects the middle ear and is typically characterized by earache. OM may be classified as acute (AOM) or chronic (COM), based on symptom duration. OM may be clinically suspected, but the diagnosis is usually confirmed by the otoscopy. Antibiotic therapy is frequently used in clinical practice. However, antibiotics often induce intestinal and respiratory dysbiosis associated with some clinical problems. A one-month course of a probiotic mixture (Abincol® containing Lactobacillus plantarum LP01 (1 billion of living cells), Lactobacillus lactis subspecies cremoris LLC02 (800 million living cells), and Lactobacillus delbrueckii LDD01 (200 million living cells), was prescribed in the Group A, and was compared with no addon treatment, such as the Group B. Patients were evaluated at baseline (T0), at the end of antibiotic treatment (T1), at the end of probiotic course (T2), and at the end of 3-month follow-up (T3).

Keywords: acute; antibiotic therapy; chronic; dysbiosis; otitis media; probiotics.

Publication types

Review

MeSH terms

Anti-Bacterial Agents / therapeutic use
Dysbiosis / drug therapy
Humans
Lactobacillus
Otitis Media* / drug therapy
Probiotics*

Substances

Anti-Bacterial Agents

Supplementary concepts

Lactobacillus delbrueckii subsp. lactis