Aim: To assess the up-to-date evidence of acupuncture for the management of cancer-related and cancer treatment-related outcomes among people with advanced cancer.
Design: Systematic review with meta-analyses involving multidimensional outcomes.
Methods: The protocol of this systematic review has been registered in PROSPERO with the registration number CRD42020212982. Six databases (including Pubmed, EMBASE, Cochrane Library, SinoMed, ClinicalTrials.gov and Chinese Clinical Trial Registry) will be searched from inception through November 2020 to identify relevant interventional trials examining acupuncture management on multidimensional outcomes in patients with advanced cancer. Main outcomes will include cancer and treatment-related symptoms, quality of life, sleep quality and adverse events. DerSimonian & Laird random-effects meta-analysis will be applied to calculate pooled relative risks for binary data and pooled weighted mean differences (WMDs) or standardized mean differences (SMDs) for continuous data. Trial quality ratings and risk of bias will be evaluated using the Cochrane Risk of Bias Tool and the Grading of Recommendations Assessment, Development and Evaluation approach.
Discussion: The efficacy of acupuncture on advanced cancer care and outcomes has not yet been determined. Palliative care for patients with advanced cancer may involve multiple challenges that include physical and mental health care. This systematic review will offer updated and comprehensive evidence of acupuncture on specific outcomes induced by advanced cancer and cancer-related treatment, which can give high level clinical recommendations to improve patient care and clinical outcomes.
目的: 评估针灸疗法的最新证据, 以便对癌症晚期患者的癌症相关和癌症治疗相关结果进行管理。 设计: 涉及多维结果的系统评价和荟萃分析。 方法: 本系统评价方案已在PROSPERO注册, 注册号为CRD42020212982。截至2020年11月, 将在六大数据库 (包括Pubmed、EMBASE、Cochrane图书馆、SinoMed、ClinicalTrials.gov和中国临床试验注册中心) 中搜索, 以确定相关介入性试验, 并检查针灸疗法对癌症晚期患者多维结果的影响。主要结果包括癌症和治疗相关症状、生活质量、睡眠质量和不良事件。DerSimonian & Laird随机效应荟萃分析将可用于计算二元数据的合并相对危险度以及连续数据的合并加权均数差 (WMD) 或标准化均数差 (SMD) 。此外, 将利用Cochrane偏倚风险工具和和推荐分级的评价、制定与评估方法评估试验质量等级和偏倚风险。 讨论: 目前并未确定针灸疗法对癌症晚期治疗的疗效和预后。癌症晚期患者的姑息治疗面临多种挑战, 包括生理和心理健康护理。本系统综述将可作为最新综合证据, 用于确定针灸疗法对癌症晚期患者和癌症相关治疗的特定结果, 从而为改善患者护理和临床疗效提供高水平的临床建议。.
Keywords: acupuncture; adjuvant treatment; advanced cancer; meta-analysis; outcome; randomized controlled trial.
© 2021 John Wiley & Sons Ltd.