Supine Parasympathetic Withdrawal and Upright Sympathetic Activation Underly Abnormalities of the Baroreflex in Postural Tachycardia Syndrome: Effects of Pyridostigmine and Digoxin

Hypertension. 2021 Apr;77(4):1234-1244. doi: 10.1161/HYPERTENSIONAHA.120.16113. Epub 2021 Jan 11.

Abstract

[Figure: see text].

Keywords: baroreflex; digoxin; modified oxford method; orthostasis; postural tachycardia syndrome; pyridostigmine.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Adult
  • Baroreflex / drug effects
  • Baroreflex / physiology
  • Blood Pressure / drug effects
  • Blood Pressure / physiology
  • Cardiotonic Agents / administration & dosage
  • Cholinesterase Inhibitors / administration & dosage
  • Digoxin / administration & dosage*
  • Dizziness / physiopathology
  • Female
  • Heart Rate / drug effects
  • Heart Rate / physiology
  • Humans
  • Hypovolemia / etiology
  • Hypovolemia / physiopathology
  • Outcome Assessment, Health Care
  • Patient Positioning / methods
  • Postural Orthostatic Tachycardia Syndrome* / diagnosis
  • Postural Orthostatic Tachycardia Syndrome* / physiopathology
  • Pyridostigmine Bromide / administration & dosage*
  • Sympathetic Nervous System / drug effects
  • Sympathetic Nervous System / physiopathology

Substances

  • Cardiotonic Agents
  • Cholinesterase Inhibitors
  • Digoxin
  • Pyridostigmine Bromide