AC/DC magnetic device for safe medical use of potentially harmful magnetic nanocarriers

Mislav Mustapić; Zvonko Glumac; Marija Heffer; Milorad Zjalić; Ivan Prološčić; Mostafa Masud; Senka Blažetić; Ana Vuković; Motasim Billah; Aslam Khan; Suzana Šegota; Md Shahriar Al Hossain

doi:10.1016/j.jhazmat.2020.124918

AC/DC magnetic device for safe medical use of potentially harmful magnetic nanocarriers

J Hazard Mater. 2021 May 5:409:124918. doi: 10.1016/j.jhazmat.2020.124918. Epub 2020 Dec 31.

Authors

Affiliations

¹ Department of Physics, University of Osijek, 31000 Osijek, Croatia. Electronic address: mmustapic@fizika.unios.hr.
² Department of Physics, University of Osijek, 31000 Osijek, Croatia.
³ Department of Medical Biology and Genetics, Faculty of Medicine, JJ Strossmayer University of Osijek, J. Huttlera 4, 31000 Osijek, Croatia.
⁴ Australian Institute for Bioengineering and Nanotechnology, University of Queensland, St. Lucia, Brisbane, QLD 4067, Australia.
⁵ Department of Biology, J.J. Strossmayer University of Osijek, Ulica Cara Hadrijana 8A, 31000 Osijek, Croatia.
⁶ Australian Institute for Bioengineering and Nanotechnology, University of Queensland, St. Lucia, Brisbane, QLD 4067, Australia; School of Mechanical and Mining Engineering, University of Queensland, St. Lucia, Brisbane, QLD 4067, Australia.
⁷ King Abdullah Institute for Nanotechnology, King Saud University, Riyadh 11451, Saudi Arabia.
⁸ Division of Physical Chemistry, Ruđer Bošković Institute, 10000 Zagreb, Croatia.
⁹ Australian Institute for Bioengineering and Nanotechnology, University of Queensland, St. Lucia, Brisbane, QLD 4067, Australia; School of Mechanical and Mining Engineering, University of Queensland, St. Lucia, Brisbane, QLD 4067, Australia. Electronic address: md.hossain@uq.edu.au.

PMID: 33422751
DOI: 10.1016/j.jhazmat.2020.124918

Abstract

Continuing our previous research work on a drug delivery system based on combined AC/DC magnetic fields, we have developed a prototype AC/DC magnetic syringe device for stimulation of drug release from drug carriers, with the options of injecting/removing drug carriers. The porous Fe₃O₄ carrier, in a dose-dependent manner, causes acute oxidative damage and reduces the viability of differentiated SH-SY5Y human neuroblastoma cells, indicating the necessity for its removal once it reaches the therapeutic concentration at the target tissue. The working mechanism of the device consists of three simple steps. First, direct injection of the drug adsorbed on the surface of a carrier via a needle inserted into the targeted area. The second step is stimulation of drug release using a combination of AC magnetic field (a coil magnetised needle with AC current) and permanent magnets (DC magnetic lens outside of the body), and the third step is removal of the drug carriers from the injected area after the completion of drug release by magnetising the tip of the needle with DC current. Removing the drug carriers allows us to avoid possible acute and long term side effects of the drug carriers in the patient's body, as well as any potential response of the body to the drug carriers.

Keywords: Cytotoxicity; Enzyme activity; Magnetic nanoparticles; Oxidative stress.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Drug Carriers*
Drug Liberation
Humans
Magnetic Fields
Magnetics
Magnets*

Substances

Drug Carriers