Expanding the View of IKK: New Substrates and New Biology

Trends Cell Biol. 2021 Mar;31(3):166-178. doi: 10.1016/j.tcb.2020.12.003.

Abstract

The inhibitor of kappa B kinase (IKK) family consists of IKKα, IKKβ, and the IKK-related kinases TBK1 and IKKε. These kinases are considered master regulators of inflammation and innate immunity via their control of the transcription factors NF-κB, IRF3, and IRF7. Novel phosphorylated substrates have been attributed to these kinases, a subset of which is not directly related to either inflammation or innate immunity. These findings have greatly expanded the perspectives on the biological activities of these kinases. In this review we highlight some of the novel substrates for this kinase family and discuss the biological implications of these phosphorylation events.

Keywords: IKKα; IKKβ; IKKε; NF-κB; TBK1; phosphorylation.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Humans
  • Immunity, Innate
  • NF-kappa B* / metabolism
  • Phosphorylation*
  • Protein Serine-Threonine Kinases*

Substances

  • NF-kappa B
  • Protein Serine-Threonine Kinases