dGTP-Templated Luminescent Gold Nanocluster-Based Composite Nanoparticles for Cancer Theranostics

ACS Biomater Sci Eng. 2018 Mar 12;4(3):1005-1012. doi: 10.1021/acsbiomaterials.7b00980. Epub 2018 Feb 2.

Abstract

dGTP-templated facile synthesis of luminescent gold nanoclusters (Au NCs) in the presence of cisplatin following PEG coating developed spherical composite NPs. The composite NPs delivered cisplatin efficiently into HeLa cells to induce apoptosis-mediated cell death, and simultaneously bioimaged the cellular uptake.

Keywords: Au nanoclusters; apoptosis; cisplatin; composite NPs; theranostic.