Generation of a hiPSC line ZZUNEUi012-A from a healthy female individual

Mengyu Wang; Yongjuan Ruan; Xiaoxu Tian; Yangyang Liu; Mengduan Liu; Wanrong Fu; Wenting Du; Jing Zhao; Liang Hu; Xiaowei Li; Xiaoyan Zhao; Jianzeng Dong

doi:10.1016/j.scr.2020.102143

Generation of a hiPSC line ZZUNEUi012-A from a healthy female individual

Stem Cell Res. 2020 Dec 26:50:102143. doi: 10.1016/j.scr.2020.102143. Online ahead of print.

Authors

Affiliations

¹ Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China; Cardiovascular Institute of Zhengzhou University, Zhengzhou 450052, China.
² Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China; Cardiovascular Institute of Zhengzhou University, Zhengzhou 450052, China; Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, National Clinical Research Centre for Cardiovascular Diseases, No. 2 Beijing Anzhen Road, Chaoyang District, Beijing 100029, China. Electronic address: jzdong@zzu.edu.cn.

PMID: 33418203
DOI: 10.1016/j.scr.2020.102143

Abstract

Induced pluripotent stem cells (iPSCs) have differentiation potential into different somatic cell types in vitro and are a useful tool to investigate pathomechanistic and cellular processes. In this study, we generated human induced pluripotent stem cells (iPSC) ZZUNEUi012-A from an apparently healthy female individual using an integration-free reprogramming method. The generated hiPSC line was pluripotent and had normal karyotype, showed robust expression of pluripotency markers and could differentiate into all three germ layers in vitro.