Anxiety in Parkinson's disease: Abnormal resting activity and connectivity

Marion Criaud; Jin-Hee Kim; Mateusz Zurowski; Nancy Lobaugh; Sofia Chavez; Sylvain Houle; Antonio P Strafella

doi:10.1016/j.brainres.2020.147235

Anxiety in Parkinson's disease: Abnormal resting activity and connectivity

Brain Res. 2021 Feb 15:1753:147235. doi: 10.1016/j.brainres.2020.147235. Epub 2021 Jan 4.

Authors

Marion Criaud¹, Jin-Hee Kim², Mateusz Zurowski³, Nancy Lobaugh⁴, Sofia Chavez⁵, Sylvain Houle⁵, Antonio P Strafella⁶

Affiliations

¹ Research Imaging Centre, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada; Division of Brain, Imaging and Behaviour - Systems Neuroscience, Krembil Research Institute, UHN, University of Toronto, Ontario, Canada. Electronic address: marion.criaud@kcl.ac.uk.
² Research Imaging Centre, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada; Division of Brain, Imaging and Behaviour - Systems Neuroscience, Krembil Research Institute, UHN, University of Toronto, Ontario, Canada.
³ Division of Brain, Imaging and Behaviour - Systems Neuroscience, Krembil Research Institute, UHN, University of Toronto, Ontario, Canada; Department of Psychiatry, University of Toronto, Ontario, Canada.
⁴ Research Imaging Centre, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada; Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada.
⁵ Research Imaging Centre, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada.
⁶ Morton and Gloria Shulman Movement Disorder Unit & E.J. Safra Parkinson Disease Program, Toronto Western Hospital, UHN, University of Toronto, Ontario, Canada; Research Imaging Centre, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada; Division of Brain, Imaging and Behaviour - Systems Neuroscience, Krembil Research Institute, UHN, University of Toronto, Ontario, Canada; Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada. Electronic address: antonio.strafella@camh.ca.

PMID: 33412150
DOI: 10.1016/j.brainres.2020.147235

Abstract

Anxiety is a very common yet poorly understood symptom of Parkinson's disease. We investigated whether Parkinson's disease patients experiencing anxiety share neural mechanisms described in the general population with involvement of critical regions for the control of behaviour and movement. Thirty-nine patients with PD were recruited for this study, 20 with higher anxiety scores and 19 with lower anxiety scores. They all underwent a resting-state fMRI scan, while they were on medication. The amplitude of low-frequency fluctuation (ALFF) and seed-based connectivity were investigated to reveal the changes of the spontaneous activity and the interaction among different related regions. The results provided evidence that anxiety in Parkinson's disease is associated with the over-activation of the amygdala and impaired inter-relationship of regions involved in behavior (i.e. medial prefrontal cortex, insula) and motor control (i.e. basal ganglia).

Keywords: Anxiety; Behaviour; Cognition; Dopamine; Non-motor symptoms; Parkinson’s disease.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aged
Anxiety / physiopathology
Anxiety Disorders / complications*
Anxiety Disorders / drug therapy
Anxiety Disorders / physiopathology
Brain / physiopathology
Female
Humans
Magnetic Resonance Imaging / methods
Male
Middle Aged
Neural Pathways / physiopathology
Parkinson Disease / complications*
Parkinson Disease / drug therapy
Parkinson Disease / physiopathology*
Rest / physiology*

Grants and funding

PJ8 169695/CAPMC/ CIHR/Canada