Gold nanoplates with superb photothermal efficiency and peroxidase-like activity for rapid and synergistic antibacterial therapy

Lu Yan; Jie Mu; Pengxin Ma; Qian Li; Pengxue Yin; Xuan Liu; Yuanyuan Cai; Haipeng Yu; Junchong Liu; Guoqing Wang; Aihua Liu

doi:10.1039/d0cc06925f

Gold nanoplates with superb photothermal efficiency and peroxidase-like activity for rapid and synergistic antibacterial therapy

Chem Commun (Camb). 2021 Feb 2;57(9):1133-1136. doi: 10.1039/d0cc06925f.

Authors

Lu Yan¹, Jie Mu¹, Pengxin Ma¹, Qian Li², Pengxue Yin¹, Xuan Liu¹, Yuanyuan Cai¹, Haipeng Yu¹, Junchong Liu¹, Guoqing Wang², Aihua Liu¹

Affiliations

¹ Institute for Chemical Biology & Biosensing, and College of Life Sciences, and School of Pharmacy, Medical College, Qingdao University, 308 Ningxia Road, Qingdao 266071, China. liuah@qdu.edu.cn.
² College of Food Science & Engineering, Ocean University of China, 5 Yushan Road, Qingdao 266003, China.

PMID: 33410850
DOI: 10.1039/d0cc06925f

Abstract

Gold nanoplates (AuNPTs) exhibit outstanding photothermal conversion efficiency (68.5%) and peroxidase-like activity. The combination of the very low H2O2 concentration (0.1 mM) and the low AuNPT dosage (50 μg mL-1) with 808 nm laser irradiation (1 W cm-2, 3 min) shows excellent synergistic antibacterial ability and healing of MRSA-infected wounds in vivo.

MeSH terms

Animals
Anti-Bacterial Agents / chemistry
Anti-Bacterial Agents / pharmacology*
Gold / chemistry*
Metal Nanoparticles / chemistry*
Methicillin-Resistant Staphylococcus aureus
Peroxidases / chemistry
Peroxidases / metabolism*
Rats
Staphylococcal Infections / drug therapy*
Staphylococcal Infections / microbiology

Substances

Anti-Bacterial Agents
Gold
Peroxidases