Design and Application in Delivery System of Intranasal Antidepressants

Jingying Xu; Jiangang Tao; Jidong Wang

doi:10.3389/fbioe.2020.626882

Design and Application in Delivery System of Intranasal Antidepressants

Front Bioeng Biotechnol. 2020 Dec 21:8:626882. doi: 10.3389/fbioe.2020.626882. eCollection 2020.

Authors

Jingying Xu^{1

2}, Jiangang Tao^{1

2}, Jidong Wang³

Affiliations

¹ School of Marxism, Yanshan University, Qinhuangdao, China.
² Mental Health Service Center, Yanshan University, Qinhuangdao, China.
³ Applied Chemistry Key Laboratory of Hebei Province, Hebei Key Laboratory of Heavy Metal Deep-Remediation in Water and Resource Reuse, Yanshan University, Qinhuangdao, China.

Abstract

One of the major reasons why depressed patients fail their treatment course is the existence of the blood-brain barrier (BBB), which prevents drugs from being delivered to the central nervous system (CNS). In recent years, nasal drug delivery has achieved better systemic bioavailability and activity in low doses in antidepressant treatment. In this review, we focused on the latest strategies for delivery carriers (or formation) of intranasal antidepressants. We began this review with an overview of the nasal drug delivery systems, including nasal drug delivery route, absorption mechanism, advantages, and limitations in the nasal drug delivery route. Next, we introduced the development of nasal drug delivery devices, such as powder devices, liquid-based devices, and so on. Finally, intranasal delivery carriers of antidepressants in clinical studies, including nanogels, nanostructured lipid, liposomes nanoparticles, nanoemulsions/microemulsion, were summarized. Moreover, challenges and future perspectives on recent progress of intranasal delivery carriers in antidepressant treatments were discussed.

Keywords: antidepressants; challenges and future perspectives; delivery carrier; design and application; intranasal route.

Publication types

Review