SARS-COV2 Alters Blood Brain Barrier Integrity Contributing to Neuro-Inflammation

J Neuroimmune Pharmacol. 2021 Mar;16(1):4-6. doi: 10.1007/s11481-020-09975-y. Epub 2021 Jan 6.

Authors

Jessica L Reynolds¹, Supriya D Mahajan²

Affiliations

¹ Department of Medicine, Division of Allergy, Immunology & Rheumatology, Jacobs School of Medicine and Biomedical Sciences, Clinical & Translational Research Center, University at Buffalo, 875 Ellicott Street, Buffalo, NY, 14203, USA.
² Department of Medicine, Division of Allergy, Immunology & Rheumatology, Jacobs School of Medicine and Biomedical Sciences, Clinical & Translational Research Center, University at Buffalo, 875 Ellicott Street, Buffalo, NY, 14203, USA. smahajan@buffalo.edu.

No abstract available

Publication types

Letter
Research Support, N.I.H., Extramural

MeSH terms

Angiotensin-Converting Enzyme 2 / physiology
Astrocytes / drug effects
Astrocytes / metabolism
Astrocytes / virology
Blood-Brain Barrier*
Brain / blood supply
COVID-19 / complications
COVID-19 / physiopathology*
Cell Line
Culture Media, Conditioned / pharmacology
Cytokine Release Syndrome / etiology
Cytokines / biosynthesis
Cytokines / genetics
Encephalitis, Viral / etiology
Encephalitis, Viral / physiopathology*
Encephalitis, Viral / virology
Endothelial Cells / drug effects
Endothelial Cells / metabolism
Endothelial Cells / virology
Gene Expression Regulation, Viral
Humans
Microvessels / virology
Oxidative Stress
Receptors, Virus / physiology
SARS-CoV-2 / pathogenicity*
SARS-CoV-2 / physiology
Spike Glycoprotein, Coronavirus / pharmacology
Spike Glycoprotein, Coronavirus / physiology
Tight Junction Proteins / biosynthesis
Tight Junction Proteins / genetics

Substances

Culture Media, Conditioned
Cytokines
Receptors, Virus
Spike Glycoprotein, Coronavirus
Tight Junction Proteins
spike protein, SARS-CoV-2
ACE2 protein, human
Angiotensin-Converting Enzyme 2

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