Mouse NTCP-Mediated Rosuvastatin Uptake In Vitro and in Slc10a1-Deficient Mice

AAPS J. 2021 Jan 6;23(1):17. doi: 10.1208/s12248-020-00540-2.

Authors

Laura E Russell¹, Marianne K DeGorter¹, Richard H Ho², Brenda F Leake², Crystal L Schmerk³, Sara E Mansell³, Richard B Kim^{4

5}

Affiliations

¹ Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada.
² Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
³ Division of Clinical Pharmacology, Department of Medicine, University of Western Ontario, London, Ontario, Canada.
⁴ Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada. Richard.Kim@lhsc.on.ca.
⁵ Division of Clinical Pharmacology, Department of Medicine, University of Western Ontario, London, Ontario, Canada. Richard.Kim@lhsc.on.ca.

PMID: 33404849
DOI: 10.1208/s12248-020-00540-2

No abstract available

Keywords: bile acid transporters; drug transporters; hepatic uptake transport; knockout mice; solute carrier (SLC) transporters.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
HeLa Cells
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors / administration & dosage
Hydroxymethylglutaryl-CoA Reductase Inhibitors / pharmacokinetics*
Liver / metabolism
Male
Mice
Mice, Knockout
Models, Animal
Organic Anion Transporters, Sodium-Dependent / genetics
Organic Anion Transporters, Sodium-Dependent / metabolism*
Rosuvastatin Calcium / administration & dosage
Rosuvastatin Calcium / pharmacokinetics*
Symporters / genetics
Symporters / metabolism*
Tissue Distribution

Substances

Hydroxymethylglutaryl-CoA Reductase Inhibitors
Organic Anion Transporters, Sodium-Dependent
Symporters
sodium-bile acid cotransporter
Rosuvastatin Calcium

Grants and funding

MOP-89753/CIHR/Canada