Objectives: In this paper, we examine if serious psychological distress (SPD), binge drinking, and self-rated health predict dual-use of tobacco cigarette and e-cigarette compared with no use or the use of only one product among Hispanics/Latinos (H/L). By increasing our understanding of determinants of dual-use, we can identify the most vulnerable groups and intervention targets. Methods: We used data from H/L who were current tobacco/nicotine users in the Houston Health Survey 2018 (N = 188; representing 158,369 individuals). We conducted descriptive, bi-variate, and multinomial logistic regression analyses, and moderation by age and sex. Results: H/L with SPD were more likely to be dual-users than non-users (Odds Ratio [OR] = 1.97), cigarette users (OR = 1.12), or e-cigarette users (OR = 2.44). Individuals who binge drank were more likely to be dual-users than non-users (OR = 2.66) or e-cigarette users (OR = 9.30), but more likely to be cigarette users compared to dual-users (OR = 2.05). Poorer self-rated health predicted an increased likelihood of being a non-user (OR = 1.19), cigarette user (OR = 1.36), and e-cigarette user compared to a dual-user (OR = 1.04). Conclusions: Behavioral health and self-rated health are important predictors of tobacco cigarette, e-cigarette, and dual-use among H/L. These relationships differ by age and sex.