Pancreatic Non-Hodgkin Lymphoma, a rare cause for obstructive jaundice. A Case reports

Abstract

Introduction: Primary pancreatic lymphoma (PPL) is an uncommon condition. Clinical features of PPL are nonspecific & likely to be misrecognized as pancreatic malignancy.

Case presentation: 71 years old male patient presented with upper abdominal pain with obstructive jaundice.

Clinical findings and investigations: Examination reveals RHC tenderness and deep icteric. CT shows a large pancreatic head and uncinate process mass. Final diagnosis made with USS guided core biopsy which confirmed B cell, Non-Hodgkin Lymphoma (NHL).

Intervention and outcome: Complete remission of PPL occurred following six cycles of chemotherapy with R-CHOP regimen.

Relevance and impact: PPL is rare condition, accounts 1% of extra nodal lymphomas and 0.5% of malignant pancreatic neoplasm. Ultrasonography, Endoscopic ultrasonography, CT and MRI are the imaging modalities use to diagnose the pancreatic neoplasm. Biopsy of all pancreatic lesion is crucial which can diagnose curable condition such as PPL. Combined therapy with chemotherapy and radiotherapy without surgery is advisable for PPL.

Keywords: Diagnosis; Primary pancreatic lymphoma; Treatment (R-CHOP regimen).