Melatonin synthesis in and uptake by mitochondria: implications for diseased cells with dysfunctional mitochondria

Russel J Reiter; Ramaswamy Sharma; Debora Aparecida Pires de Campos Zuccari; Luiz Gustavo de Almeida Chuffa; Walter Manucha; Carmen Rodriguez

doi:10.4155/fmc-2020-0326

Melatonin synthesis in and uptake by mitochondria: implications for diseased cells with dysfunctional mitochondria

Future Med Chem. 2021 Feb;13(4):335-339. doi: 10.4155/fmc-2020-0326. Epub 2021 Jan 5.

Authors

Russel J Reiter¹, Ramaswamy Sharma¹, Debora Aparecida Pires de Campos Zuccari², Luiz Gustavo de Almeida Chuffa³, Walter Manucha⁴, Carmen Rodriguez⁵

Affiliations

¹ Department of Cell Systems & Anatomy, UT Health San Antonio, San Antonio, TX 78229, USA.
² Faculdade de Medicina de São José do Rio Preto, Laboratório de Investigação Molecular do Câncer, Avenida Brigadeiro Faria Lima, 5416, Vila São Pedro, São José do Rio Preto, São Paulo 15090000, Brasil.
³ Departamento de Biologia Estrutural e Funcional, Setor de Anatomia, Instituto de Biociências, IBB/UNESP, Campus Botucatu Rua Dr. Antônio Celso Wagner Zanin, 250, Distrito de Rubião Júnior, Botucatu, São Paulo 18618-689, Brasil.
⁴ Pathology Department, Pharmacology Area, Medical Sciences College, National University of 14 Cuyo, Mendoza CP5500, Argentina.
⁵ Departamento de Morfología y Biología Celular, Facultad de Medicina, c/JulianClaveria, 6, Oviedo 33006, Spain.

PMID: 33399498
DOI: 10.4155/fmc-2020-0326

No abstract available

Keywords: Warburg effect; aerobic glycolysis; glycolytics; hypoxia-inducible factor 1α; oxidative phosphorylation; pyruvate dehydrogenase; reactive oxygen species; superoxide dismutase 2; zygote.

Publication types

Editorial

MeSH terms

Acetyl Coenzyme A / metabolism
Humans
Melatonin / biosynthesis*
Mitochondria / metabolism*
Oxidative Phosphorylation
Pyruvate Dehydrogenase Complex / metabolism

Substances

Pyruvate Dehydrogenase Complex
Acetyl Coenzyme A
Melatonin