Homochiral Metal-Organic Framework [Co(L)(bpe)2(H2O)2]·H2O Used for Separation of Racemates in High-Performance Liquid Chromatography

Yunyan Yu; Baoyan Yuan; Cong Hu; Nan Fu; Nayan Xu; Junhui Zhang; Bangjin Wang; Shengming Xie; Liming Yuan

doi:10.1093/chromsci/bmaa117

Homochiral Metal-Organic Framework [Co(L)(bpe)2(H2O)2]·H2O Used for Separation of Racemates in High-Performance Liquid Chromatography

J Chromatogr Sci. 2021 Mar 19;59(4):355-360. doi: 10.1093/chromsci/bmaa117.

Authors

Yunyan Yu¹, Baoyan Yuan¹, Cong Hu¹, Nan Fu¹, Nayan Xu¹, Junhui Zhang¹, Bangjin Wang¹, Shengming Xie¹, Liming Yuan¹

Affiliation

¹ Department of Chemistry, Yunnan Normal University, Kunming 650500, China.

PMID: 33395701
DOI: 10.1093/chromsci/bmaa117

Abstract

A homochiral metal-organic framework (MOF) comprising [Co(L)(bpe)2(H2O)2]·H2O was prepared using (1R,2R)-(-)-1,2-cyclohexanedicarboxylic acid (H2L) and 1,2-bis(4-pyridyl)-ethylene as organic ligands. The homochiral MOF [Co(L)(bpe)2(H2O)2]·H2O was explored as chiral stationary phase (CSP) for high-performance liquid chromatography (HPLC) separation of racemates. Nine racemates including naphthol, alcohol, diol, amine, ketone, ether and organic acid were well separated on the homochiral MOF [Co(L)(bpe)2(H2O)2]·H2O column (250 mm long × 4.6 mm i.d.). The relative standard deviation for five replicate separations of 1,1'-bi-2-naphthol is 0.69% for the retention time, indicating that the good reproducibility and stability of the homochiral MOF column for HPLC enantioseparation. The results indicated that the homochiral MOF as CSP is practical, which promotes the application of homochiral MOFs in HPLC.