Effect of microscopy-assisted portoenterostomy (MAPE) for biliary atresia

Pediatr Surg Int. 2021 Feb;37(2):223-228. doi: 10.1007/s00383-020-04794-x. Epub 2021 Jan 2.

Abstract

Purpose: Portoenterostomy (PE) is the standard treatment for biliary atresia (BA). However, micro-bile ducts are difficult to identify with surgical loupes and dissect systematically. We report the effects of our attempts to dissect hilar tissue using a surgical microscope.

Methods: Microscopy-assisted portoenterostomy (MAPE) was initiated in 2014. Patients born between 2000 and 2013 who underwent PE until day 70 without a surgical microscope for BA were gathered as historical control. MAPE in re-do PE cases (Re-MAPE) was evaluated in the same manner.

Results: Ten patients underwent MAPE for BA during the study period. 17 patients in the conventional PE group were gathered. In the MAPE group, the jaundice clearance rate was 80%, compared with 53% in the conventional PE group. Re-MAPE was performed in four patients, who had a jaundice clearance rate of 75%, essentially identical to the rate with initial MAPE. At age 4 years, the native liver survival rate was 58% in the MAPE group and 38% in the conventional PE group. The native liver survival rate in the Re-MAPE group was 75%.

Conclusion: MAPE is useful for sharing the surgical field during open PE in patients with BA. It may improve the rate of jaundice clearance.

Keywords: Jaundice clearance; Liver transplantation; Micro-bile duct; Native liver survival.

MeSH terms

  • Biliary Atresia / diagnosis
  • Biliary Atresia / surgery*
  • Female
  • Humans
  • Infant
  • Male
  • Microscopy / methods*
  • Portoenterostomy, Hepatic / methods*
  • Retrospective Studies
  • Surgery, Computer-Assisted / methods*
  • Treatment Outcome