Noise buffering by biomolecular condensates in glucose sensing

Abstract

Many cellular processes involve buffering mechanisms against noise to enhance state stability. Such processes include the cell cycle and the switch between respiration and fermentation. In recent years, protein aggregation/condensation has emerged as an important regulatory mechanism. In this article, we examine the regulation of Std1, an activator of the Snf1/AMPK kinase, by sequestration into foci of liquid drops, and how foci of metabolic signaling and enzymatic proteins are regulated by chaperones, anti-aggregases and by phosphorylation.

Keywords: Amyloid; Carbon source; Chaperones; Glucose; Liquid drop; Metabolic regulation; Protein aggregation; Protein condensation; SNF1.