Exhaled breath analysis in disease detection

Ting Chen; Tiannan Liu; Ting Li; Hang Zhao; Qianming Chen

doi:10.1016/j.cca.2020.12.036

Exhaled breath analysis in disease detection

Clin Chim Acta. 2021 Apr:515:61-72. doi: 10.1016/j.cca.2020.12.036. Epub 2020 Dec 31.

Authors

Ting Chen¹, Tiannan Liu¹, Ting Li², Hang Zhao¹, Qianming Chen¹

Affiliations

¹ State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, PR China.
² State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, PR China. Electronic address: liting201456@163.com.

PMID: 33387463
DOI: 10.1016/j.cca.2020.12.036

Abstract

Investigating the use of exhaled breath analysis to diagnose and monitor different diseases has attracted much interest in recent years. This review introduces conventionally used methods and some emerging technologies aimed at breath analysis and their relevance to lung disease, airway inflammation, gastrointestinal disorders, metabolic disorders and kidney diseases. One section correlates breath components and specific diseases, whereas the other discusses some unique ideas, strategies, and devices to analyze exhaled breath for the diagnosis of some common diseases. This review aims to briefly introduce the potential application of exhaled breath analysis for the diagnosis and screening of various diseases, thereby providing a new avenue for the detection of non-invasive diseases.

Keywords: Disease diagnosis; Exhaled breath; Volatile organic compounds.

Publication types

Review

MeSH terms

Breath Tests
Humans
Lung Diseases* / diagnosis
Volatile Organic Compounds*

Substances

Volatile Organic Compounds