Background: We report here the case of two coworkers infected by the same SARS-CoV-2 strain, presenting two different immunological outcomes.
Case: One patient presented a strong IgG anti-receptor-binding domain immune response correlated with a low and rapidly decreasing titer of neutralizing antibodies. The other patient had a similar strong IgG anti-receptor-binding domain immune response but high neutralizing antibody titers.
Discussion and conclusion: Thus, host individual factors may be the main drivers of the immune response varying with age and clinical severity.
Keywords: COVID-19; IgG; Neutralizing antibody; Receptor-binding domain; SARS-CoV-2.
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