Differential serological and neutralizing antibody dynamics after an infection by a single SARS-CoV-2 strain

Infection. 2021 Aug;49(4):781-783. doi: 10.1007/s15010-020-01556-8. Epub 2021 Jan 2.

Abstract

Background: We report here the case of two coworkers infected by the same SARS-CoV-2 strain, presenting two different immunological outcomes.

Case: One patient presented a strong IgG anti-receptor-binding domain immune response correlated with a low and rapidly decreasing titer of neutralizing antibodies. The other patient had a similar strong IgG anti-receptor-binding domain immune response but high neutralizing antibody titers.

Discussion and conclusion: Thus, host individual factors may be the main drivers of the immune response varying with age and clinical severity.

Keywords: COVID-19; IgG; Neutralizing antibody; Receptor-binding domain; SARS-CoV-2.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antibodies, Neutralizing / biosynthesis
  • Antibodies, Neutralizing / blood*
  • Antibodies, Viral / blood*
  • COVID-19 / immunology*
  • COVID-19 / transmission
  • Cross Infection / immunology
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Humans
  • Immunoglobulin G / biosynthesis
  • Immunoglobulin G / blood*
  • Infectious Disease Transmission, Patient-to-Professional*
  • Male
  • Middle Aged
  • Nasopharynx / virology
  • SARS-CoV-2 / classification
  • SARS-CoV-2 / genetics
  • SARS-CoV-2 / immunology*

Substances

  • Antibodies, Neutralizing
  • Antibodies, Viral
  • Immunoglobulin G