Abstract
We explored the impact of the Spanish COVID-19 strict home confinement on mental health and cognition in non-infected subjects (N = 16, 60-80 years) diagnosed with subjective cognitive decline and APOEɛ3/ɛ4 carriers. Mental health was monitored for 2 months on a daily, weekly, or monthly basis, and compared to pre-confinement values. Emotional distress, anxiety, and depression scores increased to pathological threshold values during and after confinement. Those with lower mood during confinement experienced a decline in their mood after confinement. Cognition did not change. These preliminary results suggest that mental health consequences of corona measures in preclinical stages of Alzheimer's disease should be further evaluated.
Keywords:
Alzheimer’s disease; COVID-19; confinement; mental health; subjective cognitive decline.
Publication types
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Letter
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Research Support, Non-U.S. Gov't
MeSH terms
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Aged
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Aged, 80 and over
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Alzheimer Disease / diagnosis
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Alzheimer Disease / genetics
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Alzheimer Disease / psychology*
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Anxiety Disorders / diagnosis
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Anxiety Disorders / genetics
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Anxiety Disorders / psychology
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Apolipoprotein E3 / genetics
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Apolipoprotein E4 / genetics
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COVID-19 / genetics
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COVID-19 / psychology*
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COVID-19 / therapy
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Cognition Disorders / diagnosis
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Cognition Disorders / genetics
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Cognition Disorders / psychology*
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Cognitive Dysfunction / diagnosis
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Cognitive Dysfunction / genetics
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Cognitive Dysfunction / psychology
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Depressive Disorder / diagnosis
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Depressive Disorder / genetics
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Depressive Disorder / psychology
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Female
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Humans
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Male
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Mental Health*
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Middle Aged
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Psychological Distress
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Quarantine / psychology*
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Risk
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Spain
Substances
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Apolipoprotein E3
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Apolipoprotein E4