NOX-Dependent Signaling Dysregulation in Severe COVID-19: Clues to Effective Treatments

Simona Damiano; Concetta Sozio; Giuliana La Rosa; Mariarosaria Santillo

doi:10.3389/fcimb.2020.608435

NOX-Dependent Signaling Dysregulation in Severe COVID-19: Clues to Effective Treatments

Front Cell Infect Microbiol. 2020 Dec 15:10:608435. doi: 10.3389/fcimb.2020.608435. eCollection 2020.

Authors

Simona Damiano¹, Concetta Sozio¹, Giuliana La Rosa¹, Mariarosaria Santillo¹

Affiliation

¹ Dipartimento di Medicina Clinica e Chirurgia, Università di Napoli "Federico II", Napoli, Italy.

No abstract available

Keywords: NOX enzymes; angiotensin converting enzyme 2; cardiovascular diseases; coronavirus disease 2019; diabetes; hypertension; obesity; severe acute respiratory syndrome coronavirus 2.

Publication types

Review

MeSH terms

Angiotensin-Converting Enzyme 2 / metabolism
COVID-19 / epidemiology
COVID-19 / metabolism*
COVID-19 Drug Treatment
Cardiovascular Diseases / enzymology
Cardiovascular Diseases / epidemiology
Comorbidity
Diabetes Mellitus, Type 2 / enzymology
Diabetes Mellitus, Type 2 / epidemiology
Enzyme Activation
Enzyme Inhibitors / pharmacology
Enzyme Inhibitors / therapeutic use
Humans
Metformin / pharmacology
Metformin / therapeutic use
NADPH Oxidase 2 / physiology
NADPH Oxidases / physiology*
Obesity / enzymology
Obesity / epidemiology
Oxidation-Reduction
Oxidative Stress*
Proto-Oncogene Mas
Proto-Oncogene Proteins / metabolism
Reactive Oxygen Species / metabolism
Receptors, G-Protein-Coupled / metabolism
Receptors, Virus / metabolism
Renin-Angiotensin System
SARS-CoV-2* / physiology
Signal Transduction / physiology*

Substances

Enzyme Inhibitors
Proto-Oncogene Mas
Proto-Oncogene Proteins
Reactive Oxygen Species
Receptors, G-Protein-Coupled
Receptors, Virus
Metformin
CYBB protein, human
NADPH Oxidase 2
NADPH Oxidases
ACE2 protein, human
Angiotensin-Converting Enzyme 2