Induced pluripotent stem cell line (ZZUNEUi011-A) derived from peripheral blood mononuclear cells (PBMCs) of a healthy 27-year-old female individual

Wanrong Fu; Mengyu Wang; Yangyang Liu; Mengduan Liu; Lu Wang; Liang Hu; Xiaoyan Zhao; Zhongren Ding; Xiaowei Li; Jianzeng Dong

doi:10.1016/j.scr.2020.102139

Induced pluripotent stem cell line (ZZUNEUi011-A) derived from peripheral blood mononuclear cells (PBMCs) of a healthy 27-year-old female individual

Stem Cell Res. 2020 Dec 24:50:102139. doi: 10.1016/j.scr.2020.102139. Online ahead of print.

Authors

Affiliations

¹ Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China; Cardiovascular Institute of Zhengzhou University, Zhengzhou 450052, China.
² Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China; Cardiovascular Institute of Zhengzhou University, Zhengzhou 450052, China. Electronic address: fcclixw@zzu.edu.cn.
³ Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China; Cardiovascular Institute of Zhengzhou University, Zhengzhou 450052, China; Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, National Clinical Research Centre for Cardiovascular Diseases, No. 2 Beijing Anzhen Road, Chaoyang District, Beijing 100029, China. Electronic address: jzdong@zzu.edu.cn.

PMID: 33383407
DOI: 10.1016/j.scr.2020.102139

Abstract

In this study, we report a human induced pluripotent stem cell (iPSC) line from a healthy 27-year-old female individual using non-integrative Sendai viral reprogramming technology. The cell line expresses stemness markers, exhibits a normal female karyotype, and can differentiate into three germ layers in vivo. This iPSC line from a healthy individual provides a control group for studying disease mechanisms, drug screening, and toxicity testing.