Ambient particulate matter compositions and increased oxidative stress: Exposure-response analysis among high-level exposed population

Wei Hu; Yanhua Wang; Ting Wang; Qianpeng Ji; Qiang Jia; Tao Meng; Sai Ma; Zhihu Zhang; Yanbo Li; Rui Chen; Yufei Dai; Yang Luan; Zhiwei Sun; Shuguang Leng; Huawei Duan; Yuxin Zheng

doi:10.1016/j.envint.2020.106341

Ambient particulate matter compositions and increased oxidative stress: Exposure-response analysis among high-level exposed population

Environ Int. 2021 Feb:147:106341. doi: 10.1016/j.envint.2020.106341. Epub 2020 Dec 29.

Authors

Wei Hu¹, Yanhua Wang², Ting Wang², Qianpeng Ji², Qiang Jia³, Tao Meng⁴, Sai Ma⁵, Zhihu Zhang³, Yanbo Li⁶, Rui Chen⁶, Yufei Dai², Yang Luan⁷, Zhiwei Sun⁶, Shuguang Leng¹, Huawei Duan⁸, Yuxin Zheng⁹

Affiliations

¹ School of Public Health, Qingdao University, Qingdao, China.
² Key Laboratory of Chemical Safety and Health, National Institute for Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention, Beijing, China.
³ Shandong Academy of Occupational Health and Occupational Medicine, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shangdong, China.
⁴ School of Medicine, Shanxi Datong University, Datong, China.
⁵ International Travel health Care Center, Qingdao Customs, Qingdao, China.
⁶ School of Public Health, Capital Medical University, Beijing, China.
⁷ School of Public Health, Hongqiao International Institute of Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
⁸ Key Laboratory of Chemical Safety and Health, National Institute for Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention, Beijing, China. Electronic address: duanhw@niohp.chinacdc.cn.
⁹ School of Public Health, Qingdao University, Qingdao, China. Electronic address: yxzheng@qdu.edu.cn.

PMID: 33383389
DOI: 10.1016/j.envint.2020.106341

Abstract

Background: Oxidative stress has been suggested to be one of the key drivers of health impact of particulate matter (PM). More studies on the oxidative potential of PM alone, but fewer studies have comprehensively evaluated the effects of external and internal exposure to PM compositions on oxidative stress in population.

Objective: To comprehensively investigate the exposure-response relationship between PM and its main compositions with oxidative stress indicators.

Methods: We conducted a cross-sectional study including 768 participants exposed to particulates. Environmental levels of fine particulate matter (PM_2.5), polycyclic aromatic hydrocarbons (PAHs) and metals in PM were measured, and urinary levels of PAHs metabolites and metals were measured as internal dose, respectively. Multivariable linear regression models were used to analyze the correlations of PM exposure and urinary levels of 8-hydroxy-2́'-deoxyguanosine (8-OHdG), and 8-iso-prostaglandin-F2α (8-iso-PGF2α) and malondialdehyde (MDA).

Results: The concentration of both PM_2.5 and total PAHs was significantly correlated with increased urinary 8-OHdG, 8-iso-PGF2α and MDA levels (all p < 0.05). The levels of 4 essential metals all showed significant exposure-response increase in urinary 8-OHdG in both current and non-current smokers (all p < 0.05); ambient selenium, cobalt and zinc were found to be significantly correlated with urinary 8-iso-PGF2α (p = 0.002, 0.003, 0.01, respectively); only selenium and cobalt were significantly correlated with urinary MDA (p < 0.001, 0.01, respectively). Furthermore, we found each one-unit increase in urinary total OH-PAHs generated a 0.32 increase in urinary 8-OHdG, a 0.22 increase in urinary 8-iso-PGF2α and a 0.19 increase in urinary MDA (all p < 0.001). Furthermore, it was found that the level of 12 urinary metals all showed significant and positive correlations with three oxidative stress biomarkers in all subjects (all p < 0.001).

Conclusions: Our systematic molecular epidemiological study showed that particulate matter components could induce increased oxidative stress on DNA and lipid. It may be more important to monitor and control the harmful compositions in PM rather than overall particulate mass.

Keywords: Exposure–response analysis; Heavy metals; Oxidative damage; Particulate matter; Polycyclic aromatic hydrocarbons.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

8-Hydroxy-2'-Deoxyguanosine
Biomarkers
Cross-Sectional Studies
Deoxyguanosine
Humans
Oxidative Stress
Particulate Matter* / toxicity
Polycyclic Aromatic Hydrocarbons* / analysis
Polycyclic Aromatic Hydrocarbons* / toxicity

Substances

Biomarkers
Particulate Matter
Polycyclic Aromatic Hydrocarbons
8-Hydroxy-2'-Deoxyguanosine
Deoxyguanosine