Physical fitness and activity level in Norwegian adults with achondroplasia

Am J Med Genet A. 2021 Apr;185(4):1023-1032. doi: 10.1002/ajmg.a.62055. Epub 2020 Dec 31.

Abstract

This cross-sectional Physical Fitness Study compared cardiorespiratory fitness (VO2 peak), six-minute walk test (6MWT), muscle strength (30sSTS), balance (BESS), and self-reported physical activity level (IPAQ) in Norwegian adults with achondroplasia (ACH) to reference values of average-statured individuals. The feasibility of the physical fitness tests and IPAQ was explored. Forty-three adults (22 women) participated. Mean age was 38 years (range 16-69 years). Mean differences (95% CI) for men and women with ACH compared to reference values were: VO2 peak. -7.0 m/min/kg (-13.6 to -0.5, p = .037), and - 7.9 ml/kg/min (-11.6 to -4.3, p < .001); 6MWT -270.8 m (-340.4 to -201.2, p < .001), and - 196.7 m (-244.3 to -149.0, p = .001); 30sSTS -4.6 repetitions (-7.8 to -1.5, p = .006), and - 1.1 repetitions (-3.4 to 1.1, p = .335). There were no differences within ACH participants, except for VO2 peak, where men performed better. Sufficient physical activity (> 600 metabolic equivalent of task weekly) was achieved by 79% of the participants. The feasibility of the 6MWT and 30sSTS was good. There was a strong correlation between the VO2 peak and 6MWT (men: r = 0.63, p = .007; women: r = 0.71, p < .001). The findings indicate that the 6MWT and 30sSTS test are useful in assessing functional exercise capacity and muscle strength in adults with ACH.

Keywords: achondroplasia; adult; muscle strength; physical fitness; six-minute walk test.

MeSH terms

  • Achondroplasia / epidemiology
  • Achondroplasia / physiopathology
  • Achondroplasia / therapy*
  • Activities of Daily Living*
  • Adolescent
  • Adult
  • Aged
  • Exercise Therapy*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Muscle Strength / physiology
  • Norway / epidemiology
  • Oxygen Consumption / physiology
  • Physical Fitness / physiology*
  • Walk Test
  • Young Adult