Cosmosporasides F-H, three new sugar alcohol conjugated acyclic sesquiterpenes from a Fusarium oxysporum fungus

Ying Fu; Ping Wu; Jinghua Xue; Mei Zhang; Xiaoyi Wei

doi:10.1080/14786419.2020.1864366

Cosmosporasides F-H, three new sugar alcohol conjugated acyclic sesquiterpenes from a Fusarium oxysporum fungus

Nat Prod Res. 2022 Jul;36(13):3420-3428. doi: 10.1080/14786419.2020.1864366. Epub 2020 Dec 30.

Authors

Ying Fu¹, Ping Wu², Jinghua Xue², Mei Zhang³, Xiaoyi Wei²

Affiliations

¹ Key Laboratory of Tropical Biological Resources, Ministry of Education; School of Life and Pharmaceutical Sciences, Hainan University, Haikou, China.
² Key Laboratory of Plant Resources Conservation and Sustainable Utilization/Guangdong Provincial Key Laboratory of Digital Botanical Garden, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou, PR China.
³ Beijing Center for Physical and Chemical Analysis, Beijing, China.

PMID: 33375847
DOI: 10.1080/14786419.2020.1864366

Abstract

Three new sugar alcohol conjugated acyclic sesquiterpenes, cosmosporasides F-H (1-3), were isolated from the fermented cultures of Fusarium oxysporum SC0002. Their structures were elucidated by extensive analysis of spectroscopic data, including ¹H-¹³C long-range coupling constants (J_C,H). Their antibacterial, cytotoxic and anti-inflammatory activities were evaluated.

Keywords: Cosmosporasides; Fusarium oxysporum; secondary metabolites; sugar alcohol conjugated sesquiterpenes.

MeSH terms

Fusarium* / chemistry
Sesquiterpenes* / chemistry
Sesquiterpenes* / pharmacology
Sugar Alcohols

Substances

Sesquiterpenes
Sugar Alcohols

Supplementary concepts

Fusarium oxysporum