Cigarettes smoking and androgen receptor-positive breast cancer

Eur J Cancer Prev. 2021 Nov 1;30(6):469-471. doi: 10.1097/CEJ.0000000000000661.

Abstract

Objectives: Cigarette smoking is related to higher levels of circulating androgens, but its association with androgen receptor (AR) status is still unaddressed.

Methods: We analysed, with a case-only approach, smoking habits according to AR status in 112 cases of invasive female breast cancer, from the Piedmont Cancer Registry. We used a multivariate logistic regression model to estimate the odds ratio (OR) and the corresponding confidence interval (CI).

Results: The OR of AR-positive breast cancer (versus AR-negative) for ever smokers (versus never) was 2.85 (95% CI 1.02-7.96).

Conclusion: Smoking is related to AR-positive breast cancer.

MeSH terms

  • Breast Neoplasms* / epidemiology
  • Breast Neoplasms* / etiology
  • Female
  • Humans
  • Odds Ratio
  • Receptors, Androgen
  • Smoking / adverse effects
  • Smoking / epidemiology
  • Tobacco Products*

Substances

  • Receptors, Androgen