Abstract
Accelerated long-term forgetting (ALF) refers to a rapid loss of information over days or weeks despite normal acquisition/encoding. Notwithstanding its potential relevance as a presymptomatic marker of cognitive dysfunction, no study has addressed the relationship between ALF and Alzheimer's disease (AD) biomarkers. We examined ALF in APOE ɛ4 carriers versus noncarriers, and its relationships with AD cerebrospinal fluid (CSF) biomarkers. We found ALF over three months in APOE ɛ4 carriers (F(1,19) = 5.60; P < 0.05; Cohen's d = 1.08), and this performance was associated with abnormal levels of the CSF Aβ42 /ptau ratio (r = -.614; P < 0.01). Our findings indicate that ALF is detectable in at-risk individuals, and that there is a relationship between ALF and the pathophysiological processes underlying AD.
© 2020 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Aged
-
Alzheimer Disease / cerebrospinal fluid*
-
Alzheimer Disease / genetics*
-
Alzheimer Disease / physiopathology
-
Amyloid beta-Peptides / cerebrospinal fluid
-
Apolipoproteins E / genetics*
-
Biomarkers / cerebrospinal fluid*
-
Cognitive Dysfunction / cerebrospinal fluid*
-
Cognitive Dysfunction / genetics*
-
Cognitive Dysfunction / physiopathology
-
Dementia / cerebrospinal fluid
-
Dementia / diagnosis
-
Dementia / genetics
-
Female
-
Heterozygote
-
Humans
-
Male
-
Middle Aged
-
Peptide Fragments
-
Time Factors
-
tau Proteins / cerebrospinal fluid
Substances
-
Amyloid beta-Peptides
-
Apolipoproteins E
-
Biomarkers
-
Peptide Fragments
-
amyloid beta-protein (1-42)
-
tau Proteins
Grants and funding
This work was funded by Ministerio de Ciencia, Innovación y Universidades grant PGC2018‐099859‐B‐I00; European Regional Development Fund (ERDF) grant ; Carlos III Health Institute grants AC14/00014, PI043610, and PI19/00745; Ministerio de Ciencia, Innovación y Universidades (MCIU) grant PGC2018‐099859‐B‐I00.