Phenotypic drift in metastatic progression of breast cancer: A case report with histologically heterogeneous lesions that are clonally related

Jamie R Kutasovic; Amy E McCart Reed; Anna Sokolova; Janani Jayanthan; Leonard Da Silva; Peter T Simpson; Sunil R Lakhani

doi:10.1002/ccr3.3257

Phenotypic drift in metastatic progression of breast cancer: A case report with histologically heterogeneous lesions that are clonally related

Clin Case Rep. 2020 Aug 27;8(12):2725-2731. doi: 10.1002/ccr3.3257. eCollection 2020 Dec.

Authors

Jamie R Kutasovic¹, Amy E McCart Reed¹, Anna Sokolova^{1

2}, Janani Jayanthan¹, Leonard Da Silva^{1

2}, Peter T Simpson¹, Sunil R Lakhani^{1

2}

Affiliations

¹ UQ Centre for Clinical Research, Faculty of Medicine The University of Queensland Brisbane Qld Australia.
² Pathology Queensland The Royal Brisbane and Women's Hospital Brisbane Qld Australia.

Abstract

Breast cancer metastasis to the stomach is rare; invasive lobular carcinoma has a predilection to spread to the gastrointestinal system and is morphologically similar to primary diffuse gastric carcinoma. This case highlights heterogeneous metastatic progression and that documentation of heterogeneity is important for informing future treatment strategies and prognostication.

Keywords: E‐cadherin; breast cancer; clonal progression; comparative genomic hybridization; metastasis; recurrence.

Publication types

Case Reports