Persistence of SARS-CoV-2 RNA in post-mortem swab 35 days after death: A case report

Forensic Sci Int. 2021 Feb:319:110653. doi: 10.1016/j.forsciint.2020.110653. Epub 2020 Dec 9.

Abstract

Post-mortem swabs for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) RNA detection have been recommended by several Scientific Committees and Institutions as a standard procedure for post-mortem assessment of potential Coronavirus Disease-19 (COVID-19) related deaths. To date there is no data about the SARS-CoV-2 RNA detectability period in human bodies after death. The present case documents the persistence of SARS-CoV-2 RNA in the upper respiratory tract 35-days after death. Post-mortem swabs could be used as a valuable tool in preventive evaluation of the risks-benefits ratio associated with autopsy execution. SARS-CoV-2 RNA post-mortem detection could have a key diagnostic role in deaths lacking medical assistance, unattended deaths, and patients with multiple comorbidities. Based on the present report, staged post-mortem swabs should be performed even after a long post-mortem interval.

Keywords: Autopsy; Biosafety; COVID-19; Post-mortem diagnosis; Post-mortem swab; SARS-CoV-2.

Publication types

  • Case Reports

MeSH terms

  • Cadaver*
  • Humans
  • Male
  • Middle Aged
  • Nasal Cavity / virology*
  • Oropharynx / virology*
  • RNA, Viral / isolation & purification*
  • Real-Time Polymerase Chain Reaction
  • Reverse Transcriptase Polymerase Chain Reaction
  • SARS-CoV-2 / genetics*
  • Specimen Handling
  • Time Factors

Substances

  • RNA, Viral