Candida glabrata as an aetiological factor of the fulminant course of panophthalmitis

Ann Agric Environ Med. 2020 Dec 22;27(4):540-543. doi: 10.26444/aaem/122475. Epub 2020 Jun 5.

Abstract

Introduction: The role of fungi in infections in immunocompromised patients is a growing problem in both diagnosis and treatment. Candida species are the most common cause of fungal, endogenous endophthalmitis and infections of the cornea.

Case study: A patient was admitted to hospital due to acute inflammation of the tissue of the left orbit, 1.5 years after the corneal penetrating transplantation of the left eye with intracapsular extraction of lens and simultaneous anterior vitrectomy. The microbiological system identified: Streptococcus pyogenes, Staphylococcus aureus, and Candida glabrata in the patient.

Conclusions: The factors conducive to fungal infections are: patient's old age, immune disorders and diabetes, as well as the presence of a necrotic tissue or a foreign body. All these parameters were met in this case. Only antibiotic therapy and long-term antifungal therapy, together with surgical debridement of the site of the ongoing infection produces clinical effects in such severe cases.

Keywords: Corneal transplant; candida glabrata; panophthalmitis.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Anti-Bacterial Agents / therapeutic use
  • Antifungal Agents / therapeutic use*
  • Candida glabrata / isolation & purification*
  • Candidiasis / diagnosis*
  • Candidiasis / microbiology
  • Candidiasis / physiopathology
  • Debridement*
  • Eye Infections, Fungal / diagnosis*
  • Eye Infections, Fungal / microbiology
  • Female
  • Humans
  • Panophthalmitis / diagnosis*
  • Panophthalmitis / microbiology
  • Poland
  • Staphylococcal Infections / diagnosis
  • Staphylococcal Infections / microbiology
  • Staphylococcal Infections / therapy
  • Staphylococcus aureus / isolation & purification
  • Streptococcal Infections / diagnosis
  • Streptococcal Infections / microbiology
  • Streptococcal Infections / therapy
  • Streptococcus pyogenes / isolation & purification
  • Treatment Outcome

Substances

  • Anti-Bacterial Agents
  • Antifungal Agents