Bromodomain-containing protein 4 and its role in cardiovascular diseases

J Cell Physiol. 2021 Jul;236(7):4829-4840. doi: 10.1002/jcp.30225. Epub 2020 Dec 20.

Abstract

Bromodomain-containing protein 4 (BRD4), a chromatin-binding protein, is involved in the development of various tumors. Recent evidence suggests that BRD4 also plays a significant role in cardiovascular diseases, such as ischemic heart disease, hypertension, and cardiac hypertrophy. This review summarizes the roles of BRD4 as a potential regulator of various pathophysiological processes in cardiovascular diseases, implicating that BRD4 may be a new therapeutic target for cardiovascular diseases in the future.

Keywords: BRD4; cardiac hypertrophy; cardiovascular diseases; hypertension; ischemic heart disease.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Cardiomegaly / pathology*
  • Cell Cycle Proteins / metabolism*
  • Humans
  • Hypertension / pathology*
  • Myocardial Ischemia / pathology*
  • Protein Conformation
  • Transcription Factors / metabolism*
  • Transcription, Genetic / genetics
  • Transcriptional Activation / genetics
  • Vascular Remodeling / physiology
  • Ventricular Remodeling / physiology*

Substances

  • BRD4 protein, human
  • Cell Cycle Proteins
  • Transcription Factors