B regulatory cells in allergy

Siyuan Ma; Pattraporn Satitsuksanoa; Kirstin Jansen; Lacin Cevhertas; Willem van de Veen; Mübeccel Akdis

doi:10.1111/imr.12937

B regulatory cells in allergy

Immunol Rev. 2021 Jan;299(1):10-30. doi: 10.1111/imr.12937. Epub 2020 Dec 21.

Authors

Siyuan Ma^{1

2}, Pattraporn Satitsuksanoa¹, Kirstin Jansen¹, Lacin Cevhertas^{1

3}, Willem van de Veen¹, Mübeccel Akdis¹

Affiliations

¹ Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.
² Department of Otolaryngology Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing, China.
³ Department of Medical Immunology, Institute of Health Sciences, Bursa Uludag University, Bursa, Turkey.

PMID: 33345311
DOI: 10.1111/imr.12937

Abstract

B cells have classically been recognized for their unique and indispensable role in the production of antibodies. Their potential as immunoregulatory cells with anti-inflammatory functions has received increasing attention during the last two decades. Herein, we highlight pioneering studies in the field of regulatory B cell (Breg) research. We will review the literature on Bregs with a particular focus on their role in the regulation of allergic inflammation.

Keywords: Breg cells; IL-10; allergen immunotherapy; tolerance.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Anti-Inflammatory Agents
B-Lymphocytes, Regulatory*
Humans
Hypersensitivity*
Inflammation

Substances

Anti-Inflammatory Agents