Wnt signalling pathway in bladder cancer

Guanlin Wu; Weidong Weng; Pengfei Xia; Shixian Yan; Cheng Zhong; Lei Xie; Yu Xie; Gang Fan

doi:10.1016/j.cellsig.2020.109886

Wnt signalling pathway in bladder cancer

Cell Signal. 2021 Mar:79:109886. doi: 10.1016/j.cellsig.2020.109886. Epub 2020 Dec 17.

Authors

Guanlin Wu¹, Weidong Weng², Pengfei Xia³, Shixian Yan⁴, Cheng Zhong⁵, Lei Xie⁶, Yu Xie⁷, Gang Fan⁸

Affiliations

¹ Experimental and Clinical Research Center, Charité-Universitätsmedizin Berlin, Berlin 13125, Germany; Max Delbrück Center for Molecular Medicine (MDC) in the Helmholtz Association, Berlin 13125, Germany. Electronic address: wuguanlin105109@gmail.com.
² Siegfried Weller Research Institute, BG Unfallklinik Tübingen, Department of Trauma and Reconstructive Surgery, University of Tübingen, Schnarrenbergstr. 95, Tübingen D-72076, Germany. Electronic address: wengweidong5657@gmail.com.
³ Experimental and Clinical Research Center, Charité-Universitätsmedizin Berlin, Berlin 13125, Germany; Max Delbrück Center for Molecular Medicine (MDC) in the Helmholtz Association, Berlin 13125, Germany. Electronic address: Pengfei.Xia@mdc-berlin.de.
⁴ Experimental and Clinical Research Center, Charité-Universitätsmedizin Berlin, Berlin 13125, Germany; Max Delbrück Center for Molecular Medicine (MDC) in the Helmholtz Association, Berlin 13125, Germany. Electronic address: Shixan.Yan@mdc-berlin.de.
⁵ Experimental and Clinical Research Center, Charité-Universitätsmedizin Berlin, Berlin 13125, Germany; Institute of Vegetative Physiology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin 10117, Germany. Electronic address: cheng.zhong@charite.de.
⁶ Department of Urology, Huazhong University of Science and Technology Union Shenzhen Hospital, Shenzhen 518052, China. Electronic address: xie_lei@aliyun.com.
⁷ Department of Urology, the Affiliated Cancer Hospital of Xiangya School of Medicine of Central South University, Hunan Cancer Hospital, Changsha, Hunan 410013, China. Electronic address: 1715840770@qq.com.
⁸ Department of Urology, Huazhong University of Science and Technology Union Shenzhen Hospital, Shenzhen 518052, China; Department of Urology, the Affiliated Cancer Hospital of Xiangya School of Medicine of Central South University, Hunan Cancer Hospital, Changsha, Hunan 410013, China; The 6th Affiliated Hospital of Shenzhen University Health Science Center, Shenzhen 518060, China. Electronic address: gang.fan.med@qq.com.

PMID: 33340660
DOI: 10.1016/j.cellsig.2020.109886

Abstract

Bladder cancer (BC) is one of the most common tumours of the urinary system and is also known as a highly malignant tumour. In addition to conventional diagnosis and treatment methods, recent research has focused on studying the molecular mechanisms related to BC, in the hope that new, less toxic and effective targeted anticancer drugs and new diagnostic markers can be discovered. It is known that the Wingless (Wnt) signalling pathway and its related genes, proteins and other substances are involved in multiple biological processes of various tumours. Clarifying the contribution of the Wnt signalling pathway in bladder tumours will help establish early diagnosis indicators, develop new therapeutic drugs and evaluate the prognosis for BC. This review aims to summarise previous studies related to BC and the Wnt signalling pathway, with a focus on exploring the participating substances and their mechanisms in the regulation of the Wnt signalling pathway to better determine how to promote new chemotherapeutic drugs, potential therapeutic targets and diagnostic biomarkers.

Keywords: Bladder cancer; Urothelial carcinoma; Wnt signalling pathway.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Gene Expression Regulation, Neoplastic*
Humans
Neoplasm Proteins / genetics
Neoplasm Proteins / metabolism*
Urinary Bladder Neoplasms / genetics
Urinary Bladder Neoplasms / metabolism*
Wnt Signaling Pathway*

Substances

Neoplasm Proteins