Q's the Boss: Gαq Regulates Gi-Mediated Calcium Release through PLCβ

Isaac J Fisher; Angeline M Lyon

doi:10.1016/j.molcel.2020.11.038

Q's the Boss: Gα_q Regulates G_i-Mediated Calcium Release through PLCβ

Mol Cell. 2020 Dec 17;80(6):933-934. doi: 10.1016/j.molcel.2020.11.038.

Authors

Isaac J Fisher¹, Angeline M Lyon²

Affiliations

¹ Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, USA; Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907, USA.
² Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, USA; Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907, USA. Electronic address: lyonam@purdue.edu.

PMID: 33338407
DOI: 10.1016/j.molcel.2020.11.038

Abstract

Pfeil et al., (2020) examine the mechanism of G_i-stimulated Ca²⁺ release in cells and find an unexpected role for Gα_q in Gβγ-dependent activation of phospholipase Cβ (PLCβ).

Publication types

Comment

MeSH terms

Calcium* / metabolism
GTP-Binding Protein alpha Subunits, Gq-G11* / metabolism
Phospholipase C beta / genetics
Phospholipase C beta / metabolism
Signal Transduction

Substances

Phospholipase C beta
GTP-Binding Protein alpha Subunits, Gq-G11
Calcium