Darier sign in a teenager with primary cutaneous marginal zone lymphoma

Nicholas Leonard; Karan Lal; Christina Luffman; Patrick O'Donnell; Lindsey Jolley; Leah Belazarian

doi:10.1111/pde.14488

Darier sign in a teenager with primary cutaneous marginal zone lymphoma

Pediatr Dermatol. 2021 Mar;38(2):494-496. doi: 10.1111/pde.14488. Epub 2020 Dec 18.

Authors

Nicholas Leonard¹, Karan Lal¹, Christina Luffman^{1

2}, Patrick O'Donnell^{1

2}, Lindsey Jolley¹, Leah Belazarian¹

Affiliations

¹ Department of Dermatology, University of Massachusetts Medical School, Worcester, MA, USA.
² Department of Pathology, University of Massachusetts Medical School, Worcester, MA, USA.

PMID: 33336458
DOI: 10.1111/pde.14488

Abstract

Primary cutaneous marginal zone lymphoma (PCMZL) is a low-grade B-cell lymphoma that arises in the skin. An adolescent male presented with dermal nodules on the arms, legs, and back with a positive Darier sign, ultimately diagnosed as PCMZL. The nodules demonstrated a partial response to doxycycline in the setting of prior Lyme disease followed by a complete response to rituximab.

Keywords: malignant neoplasms; systemic therapy; urticaria.

MeSH terms

Adolescent
Humans
Lymphoma, B-Cell, Marginal Zone* / diagnosis
Lymphoma, B-Cell, Marginal Zone* / drug therapy
Male
Neoplasms, Connective Tissue*
Rituximab / therapeutic use
Skin
Skin Neoplasms* / diagnosis
Skin Neoplasms* / drug therapy

Substances

Rituximab