Antiviral Effector RTP4 Bats against Flaviviruses

Joshua R Nielsen; Helen M Lazear

doi:10.1016/j.immuni.2020.11.019

Antiviral Effector RTP4 Bats against Flaviviruses

Immunity. 2020 Dec 15;53(6):1133-1135. doi: 10.1016/j.immuni.2020.11.019.

Authors

Joshua R Nielsen¹, Helen M Lazear²

Affiliations

¹ Department of Microbiology & Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
² Department of Microbiology & Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Electronic address: helen.lazear@med.unc.edu.

Abstract

Bats harbor diverse viruses and manifest distinct antiviral immune responses. Recently in Cell Host & Microbe, Boys et al. demonstrated that bat receptor transporter protein 4 (RTP4) is an innate antiviral effector that inhibits flavivirus replication, revealing an evolutionary arms race between flaviviruses and their hosts.

Publication types

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MeSH terms

Animals
Antiviral Agents
Chiroptera*
DNA Viruses
Flavivirus*
Viruses*

Substances

Antiviral Agents