Advances in Studies on the Pharmacological Activities of Fucoxanthin

Mar Drugs. 2020 Dec 11;18(12):634. doi: 10.3390/md18120634.

Abstract

Fucoxanthin is a natural carotenoid derived mostly from many species of marine brown algae. It is characterized by small molecular weight, is chemically active, can be easily oxidized, and has diverse biological activities, thus protecting cell components from ROS. Fucoxanthin inhibits the proliferation of a variety of cancer cells, promotes weight loss, acts as an antioxidant and anti-inflammatory agent, interacts with the intestinal flora to protect intestinal health, prevents organ fibrosis, and exerts a multitude of other beneficial effects. Thus, fucoxanthin has a wide range of applications and broad prospects. This review focuses primarily on the latest progress in research on its pharmacological activity and underlying mechanisms.

Keywords: anti-obesity; anticancer; fucoxanthin; intestinal flora; pharmacological activities; stability.

Publication types

  • Review

MeSH terms

  • Animals
  • Anti-Inflammatory Agents / isolation & purification
  • Anti-Inflammatory Agents / pharmacology*
  • Anti-Obesity Agents / isolation & purification
  • Anti-Obesity Agents / pharmacology*
  • Antineoplastic Agents / isolation & purification
  • Antineoplastic Agents / pharmacology*
  • Antioxidants / isolation & purification
  • Antioxidants / pharmacology*
  • Drug Stability
  • Gastrointestinal Microbiome / drug effects
  • Humans
  • Phaeophyceae* / metabolism
  • Xanthophylls / isolation & purification
  • Xanthophylls / pharmacology*

Substances

  • Anti-Inflammatory Agents
  • Anti-Obesity Agents
  • Antineoplastic Agents
  • Antioxidants
  • Xanthophylls
  • fucoxanthin