The effect of hepatitis B vaccination after five years on an entire population in an insular region of Southeast China

Ying Liu; Jingjing Ren; Zikang Wu; Lingzhi Shen; Huan Shan; Xuewei Dai; Jing Li; Yan Qiu; Wen Ren; Jun Yao; Lanjuan Li

doi:10.1080/21645515.2020.1814096

The effect of hepatitis B vaccination after five years on an entire population in an insular region of Southeast China

Hum Vaccin Immunother. 2021 May 4;17(5):1530-1535. doi: 10.1080/21645515.2020.1814096. Epub 2020 Dec 14.

Authors

Ying Liu¹, Jingjing Ren¹, Zikang Wu², Lingzhi Shen³, Huan Shan⁴, Xuewei Dai⁵, Jing Li⁶, Yan Qiu¹, Wen Ren¹, Jun Yao³, Lanjuan Li⁷

Affiliations

¹ The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
² Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
³ Department of Immunology, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, China.
⁴ Department of Quality Management, Zhejiang Hospital, Hangzhou, China.
⁵ Jingdezhen Center for Disease Control and Prevention, Jingdezhen, Jiangxi, China.
⁶ Department of Information, Zhejiang Hospital, Hangzhou, China.
⁷ State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.

Abstract

Prevalence of hepatitis B (HB) remains high among adults in insular regions of southeast China. To address this issue, large-scale HB vaccination was implemented in Putuo County of Zhoushan City in 2013. To examine the effects of this large-scale HB vaccination, a cross-sectional serological survey was conducted on two isolated islands, Putuo (intervention group) and Dinghai (control group) Counties of Zhoushan City in southeastern China five years later. The data showed lower prevalence of HBsAg and negative results for all HBV markers in the intervention group compared to the control group (4.2% and 6.0%, 20.8% and 33.0%), while the positive rate for anti-HBs and only anti-HBs were higher (68.4% and 53.4%, 47.9% and 34.3%). Therefore, large-scale adult HB vaccination could lower the HB epidemic level. However, the proportion of susceptible people who were negative for all HBV markers remained high. Hence, several additional measures to limit the spread of HBV should be taken by the government.

Keywords: Hepatitis B virus; immune effect; immunization; vaccination; vaccine.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
China
Cross-Sectional Studies
Hepatitis B Antibodies*
Hepatitis B Surface Antigens
Hepatitis B Vaccines
Hepatitis B virus
Hepatitis B*
Humans
Vaccination

Substances

Hepatitis B Antibodies
Hepatitis B Surface Antigens
Hepatitis B Vaccines

Grants and funding

This study was supported by the National Scientific and Technological Major Project of China (No. 2018ZX10715014, No. 2017ZX10105001, No. 2013ZX10004-904, and No. 2014ZX10004008).