Plasma levels of interleukin-38 in healthy aging and in type 2 diabetes

Felicia Gurău; Andrea Silvestrini; Giulia Matacchione; Francesca Fazioli; Anna Rita Bonfigli; Fabiola Olivieri; Jacopo Sabbatinelli

doi:10.1016/j.diabres.2020.108585

Plasma levels of interleukin-38 in healthy aging and in type 2 diabetes

Diabetes Res Clin Pract. 2021 Jan:171:108585. doi: 10.1016/j.diabres.2020.108585. Epub 2020 Dec 10.

Authors

Felicia Gurău¹, Andrea Silvestrini¹, Giulia Matacchione², Francesca Fazioli¹, Anna Rita Bonfigli³, Fabiola Olivieri⁴, Jacopo Sabbatinelli¹

Affiliations

¹ Department of Clinical and Molecular Sciences, DISCLIMO, Università Politecnica delle Marche, Ancona, Italy.
² Department of Clinical and Molecular Sciences, DISCLIMO, Università Politecnica delle Marche, Ancona, Italy. Electronic address: g.matacchione@pm.univpm.it.
³ Scientific Direction, IRCCS INRCA, Ancona, Italy.
⁴ Department of Clinical and Molecular Sciences, DISCLIMO, Università Politecnica delle Marche, Ancona, Italy; Center of Clinical Pathology and Innovative Therapy, IRCCS INRCA, Ancona, Italy.

PMID: 33310128
DOI: 10.1016/j.diabres.2020.108585

Abstract

Plasma levels of interleukin (IL)-38 were evaluated in patients with type 2 diabetes (T2DM) and healthy controls. Plasma IL-38 was higher in T2DM patients and positively related to waist/hip ratio, HbA1c, uric acid, liver function tests, triglycerides and total proteins. Patients suffering from diabetic nephropathy had the highest IL-38 levels.

Keywords: Age-related diseases; Aging; Inflammation; Interleukin-38; Type 2 diabetes.

MeSH terms

Age Factors
Aged
Case-Control Studies
Diabetes Mellitus, Type 2 / blood*
Female
Humans
Interleukins / blood*
Male

Substances

IL-38 protein, human
Interleukins